Characteristics and occurrence of speech impairment in Huntington's disease: possible influence of antipsychotic medication

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284398" target="_blank" >RIV/00216208:11110/14:10284398 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/14:00221819 RIV/00064165:_____/14:10284398

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00702-014-1229-8" target="_blank" >http://dx.doi.org/10.1007/s00702-014-1229-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-014-1229-8" target="_blank" >10.1007/s00702-014-1229-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Characteristics and occurrence of speech impairment in Huntington's disease: possible influence of antipsychotic medication

Popis výsledku v původním jazyce

Although motor speech impairment is a common manifestation of Huntington's disease (HD), its description remains limited. The aim of the current study was therefore to estimate the occurrence and characteristics of speech disorder in HD and to explore the influence of antipsychotic medication on speech performance. Speech samples, including reading passage and monologue, were acquired from 40 individuals diagnosed with HD and 40 age- and sex-matched healthy controls. Objective acoustic analyses were used to evaluate key aspects of speech including vowel articulation, intensity, pitch and timing. A predictive model was constructed to detect the occurrence and most prominent patterns of speech dysfunction in HD. We revealed that 93 % of HD patients manifest some degree of speech impairment. Decreased number of pauses, slower articulation rate, imprecise vowel articulation and excess intensity variations were found to be the most salient patterns of speech dysfunction in HD. We further de

Název v anglickém jazyce

Characteristics and occurrence of speech impairment in Huntington's disease: possible influence of antipsychotic medication

Popis výsledku anglicky

Although motor speech impairment is a common manifestation of Huntington's disease (HD), its description remains limited. The aim of the current study was therefore to estimate the occurrence and characteristics of speech disorder in HD and to explore the influence of antipsychotic medication on speech performance. Speech samples, including reading passage and monologue, were acquired from 40 individuals diagnosed with HD and 40 age- and sex-matched healthy controls. Objective acoustic analyses were used to evaluate key aspects of speech including vowel articulation, intensity, pitch and timing. A predictive model was constructed to detect the occurrence and most prominent patterns of speech dysfunction in HD. We revealed that 93 % of HD patients manifest some degree of speech impairment. Decreased number of pauses, slower articulation rate, imprecise vowel articulation and excess intensity variations were found to be the most salient patterns of speech dysfunction in HD. We further de

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

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Svazek periodika

121

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

11

Strana od-do

1529-1539

Kód UT WoS článku

000345409000007

EID výsledku v databázi Scopus

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