Could Antipsychotic Medication Influence Speech In Huntington?s Disease?
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F14%3A00219873" target="_blank" >RIV/68407700:21230/14:00219873 - isvavai.cz</a>
Výsledek na webu
<a href="http://jnnp.bmj.com/content/85/Suppl_1/A71.1.abstract?sid=757c8a68-2146-4296-a203-31c2fb275b77" target="_blank" >http://jnnp.bmj.com/content/85/Suppl_1/A71.1.abstract?sid=757c8a68-2146-4296-a203-31c2fb275b77</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/jnnp-2014-309032.200" target="_blank" >10.1136/jnnp-2014-309032.200</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Could Antipsychotic Medication Influence Speech In Huntington?s Disease?
Popis výsledku v původním jazyce
Background Hyperkinetic dysarthria is a common sign of Huntington?s disease (HD). Although antipsychotic medication alone can induce hyperkinetic dysarthria, its effect on speech in HD remains unknown. Aim The aim of the current study was to survey if antipsychotic medication can influence speech in HD. Methods We studied 40 patients diagnosed with HD, 22 of them were treated with antipsychotic medication (HD-AP) whereas 18 patients received no antipsychotic therapy (HD-NoAP). As controls, 40 age- and sex-matched healthy subjects were also investigated. All participants performed short reading passage for subsequent quantitative acoustic analyses of vowel articulation, intensity, pitch, and speech timing. Results When compared to controls, both HD-AP and HD-NoAP patients demonstrated significantly slower articulation rate and decreased number of pauses (p < 0.001). HD-NoAp group showed significantly decreased pitch variation (p < 0.05) whereas intensity variation was increased in HD-AP
Název v anglickém jazyce
Could Antipsychotic Medication Influence Speech In Huntington?s Disease?
Popis výsledku anglicky
Background Hyperkinetic dysarthria is a common sign of Huntington?s disease (HD). Although antipsychotic medication alone can induce hyperkinetic dysarthria, its effect on speech in HD remains unknown. Aim The aim of the current study was to survey if antipsychotic medication can influence speech in HD. Methods We studied 40 patients diagnosed with HD, 22 of them were treated with antipsychotic medication (HD-AP) whereas 18 patients received no antipsychotic therapy (HD-NoAP). As controls, 40 age- and sex-matched healthy subjects were also investigated. All participants performed short reading passage for subsequent quantitative acoustic analyses of vowel articulation, intensity, pitch, and speech timing. Results When compared to controls, both HD-AP and HD-NoAP patients demonstrated significantly slower articulation rate and decreased number of pauses (p < 0.001). HD-NoAp group showed significantly decreased pitch variation (p < 0.05) whereas intensity variation was increased in HD-AP
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/GAP102%2F12%2F2230" target="_blank" >GAP102/12/2230: Analýza hlasu a řeči pacientů s onemocněními centrální nervové soustavy</a><br>
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů