Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10284431" target="_blank" >RIV/00216208:11110/14:10284431 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/86652036:_____/14:00432492 RIV/68378041:_____/14:00432492

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.dnarep.2014.01.016" target="_blank" >http://dx.doi.org/10.1016/j.dnarep.2014.01.016</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.dnarep.2014.01.016" target="_blank" >10.1016/j.dnarep.2014.01.016</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity

Popis výsledku v původním jazyce

The interplay between dietary habits and individual genetic make-up is assumed to influence risk of cancer, via modulation of DNA integrity. Our aim was to characterize internal and external factors that underlie inter-individual variability in DNA damage and repair and to identify dietary habits beneficial for maintaining DNA integrity. Habitual diet was estimated in 340 healthy individuals using a food frequency questionnaire and biomarkers of antioxidant status were quantified in fasting blood samples. Markers of DNA integrity were represented by DNA strand breaks, oxidized purines, oxidized pyrimidines and a sum of all three as total DNA damage. DNA repair was characterized by genetic variants and functional activities of base and nucleotide excision repair pathways. Sex, fruit-based food consumption and XPG genotype were factors significantly associated with the level of DNA damage. DNA damage was higher in women (p = 0.035). Fruit consumption was negatively associated with the nu

Název v anglickém jazyce

Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity

Popis výsledku anglicky

The interplay between dietary habits and individual genetic make-up is assumed to influence risk of cancer, via modulation of DNA integrity. Our aim was to characterize internal and external factors that underlie inter-individual variability in DNA damage and repair and to identify dietary habits beneficial for maintaining DNA integrity. Habitual diet was estimated in 340 healthy individuals using a food frequency questionnaire and biomarkers of antioxidant status were quantified in fasting blood samples. Markers of DNA integrity were represented by DNA strand breaks, oxidized purines, oxidized pyrimidines and a sum of all three as total DNA damage. DNA repair was characterized by genetic variants and functional activities of base and nucleotide excision repair pathways. Sex, fruit-based food consumption and XPG genotype were factors significantly associated with the level of DNA damage. DNA damage was higher in women (p = 0.035). Fruit consumption was negatively associated with the nu

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP304%2F12%2F1585" target="_blank" >GAP304/12/1585: Molekulární charakteristiky DNA opravy v nádorových tkáních karcinomu tlustého střeva a konečníku</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

DNA Repair

ISSN

1568-7864

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

neuveden

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

66-73

Kód UT WoS článku

000335105400008

EID výsledku v databázi Scopus

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