Glycemic Variability Is Higher in Type 1 Diabetes Patients with Microvascular Complications Irrespective of Glycemic Control

Kód výsledku v IS VaVaI

RIV/00216208:11110/14:10285354 - isvavai.cz

Nalezeny alternativní kódy

RIV/00064165:_____/14:10285354

Výsledek na webu

http://dx.doi.org/10.1089/dia.2013.0205

DOI - Digital Object Identifier

10.1089/dia.2013.0205

Jazyk výsledku

angličtina

Název v původním jazyce

Glycemic Variability Is Higher in Type 1 Diabetes Patients with Microvascular Complications Irrespective of Glycemic Control

Popis výsledku v původním jazyce

Background: Increased glycemic variability (GV) may be associated with diabetes complications. Our study assessed the relationship between microvascular complications (MVCs) and GV calculated from continuous glucose monitoring (CGM) data in type 1 diabetes patients. Subjects and Methods: Thirty-two patients with type 1 diabetes (16 with and 16 without MVC) participated in this cross-sectional study. Vibration perception threshold (VPT), microalbuminuria, and fundoscopy were used to detect MVC. CGM datawere recorded for 2 weeks and analyzed using proprietary software. Total SD (SDT), coefficient of variation (CV), and mean amplitude of glycemic excursions (MAGE) were compared. Results: Patients with any MVC had significantly higher GV, calculated fromCGM, than patients without MVC (SDT, 4.10.6 vs. 3.4 +/- 0.8 mmol/L [P=0.010]; CV, 0.43 +/- 0.06 vs. 0.38 +/- 0.08 [P=0.032]; MAGE, 6.9 +/- 1.2 vs. 5.9 +/- 1.2 mmol/L [P=0.014]) but comparable glycated hemoglobin (HbA(1c)) (70 +/- 9 vs. 69

Název v anglickém jazyce

Glycemic Variability Is Higher in Type 1 Diabetes Patients with Microvascular Complications Irrespective of Glycemic Control

Popis výsledku anglicky

Background: Increased glycemic variability (GV) may be associated with diabetes complications. Our study assessed the relationship between microvascular complications (MVCs) and GV calculated from continuous glucose monitoring (CGM) data in type 1 diabetes patients. Subjects and Methods: Thirty-two patients with type 1 diabetes (16 with and 16 without MVC) participated in this cross-sectional study. Vibration perception threshold (VPT), microalbuminuria, and fundoscopy were used to detect MVC. CGM datawere recorded for 2 weeks and analyzed using proprietary software. Total SD (SDT), coefficient of variation (CV), and mean amplitude of glycemic excursions (MAGE) were compared. Results: Patients with any MVC had significantly higher GV, calculated fromCGM, than patients without MVC (SDT, 4.10.6 vs. 3.4 +/- 0.8 mmol/L [P=0.010]; CV, 0.43 +/- 0.06 vs. 0.38 +/- 0.08 [P=0.032]; MAGE, 6.9 +/- 1.2 vs. 5.9 +/- 1.2 mmol/L [P=0.014]) but comparable glycated hemoglobin (HbA(1c)) (70 +/- 9 vs. 69

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diabetes Technology and Therapeutics

ISSN

1520-9156

e-ISSN

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Svazek periodika

16

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

198-203

Kód UT WoS článku

000332701700002

EID výsledku v databázi Scopus

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