Pharmacokinetics of imipenem in critically ill patients during empirical treatment of nosocomial pneumonia: A comparison of 0.5-h and 3-h infusions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10286780" target="_blank" >RIV/00216208:11110/14:10286780 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/14:33149585 RIV/00098892:_____/14:#0000685 RIV/00064165:_____/14:10286780

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ijantimicag.2014.05.011" target="_blank" >http://dx.doi.org/10.1016/j.ijantimicag.2014.05.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijantimicag.2014.05.011" target="_blank" >10.1016/j.ijantimicag.2014.05.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pharmacokinetics of imipenem in critically ill patients during empirical treatment of nosocomial pneumonia: A comparison of 0.5-h and 3-h infusions

Popis výsledku v původním jazyce

In critically ill patients, pathophysiological changes alter the pharmacokinetics of antibiotics. Imipenem exhibits primarily time-dependent killing. Its administration by prolonged infusion may increase the time for which its plasma concentration exceeds the minimum inhibitory concentrations (MICs) of suspected pathogens. The objectives of this study were to compare the pharmacokinetic parameters of imipenem administered by standard short infusion (1 g imipenem/1 g cilastatin over 30 min three times daily) and by extended infusion with a reduced total dose (0.5 g imipenem/0.5 g cilastatin over 3 h four times daily) and to compare the target pharmacokinetic/pharmacodynamic indices, namely percentage of the dosing interval for which the free plasma concentration of imipenem exceeds the MIC and 4x MIC (%fT(>MIC) and %fT(>4xMIC)) of 0.5, 1, 2 and 4 mg/L, for these two regimens in critically ill adult patients with nosocomial pneumonia on Day 2 of empirical antibiotic therapy. The study in

Název v anglickém jazyce

Pharmacokinetics of imipenem in critically ill patients during empirical treatment of nosocomial pneumonia: A comparison of 0.5-h and 3-h infusions

Popis výsledku anglicky

In critically ill patients, pathophysiological changes alter the pharmacokinetics of antibiotics. Imipenem exhibits primarily time-dependent killing. Its administration by prolonged infusion may increase the time for which its plasma concentration exceeds the minimum inhibitory concentrations (MICs) of suspected pathogens. The objectives of this study were to compare the pharmacokinetic parameters of imipenem administered by standard short infusion (1 g imipenem/1 g cilastatin over 30 min three times daily) and by extended infusion with a reduced total dose (0.5 g imipenem/0.5 g cilastatin over 3 h four times daily) and to compare the target pharmacokinetic/pharmacodynamic indices, namely percentage of the dosing interval for which the free plasma concentration of imipenem exceeds the MIC and 4x MIC (%fT(>MIC) and %fT(>4xMIC)) of 0.5, 1, 2 and 4 mg/L, for these two regimens in critically ill adult patients with nosocomial pneumonia on Day 2 of empirical antibiotic therapy. The study in

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Antimicrobial Agents

ISSN

0924-8579

e-ISSN

—

Svazek periodika

44

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

358-362

Kód UT WoS článku

000343109600014

EID výsledku v databázi Scopus

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