Acute methanol poisonings: Folates administration and visual sequelae

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10287116" target="_blank" >RIV/00216208:11110/14:10287116 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388955:_____/14:00434535 RIV/00064165:_____/14:10287116

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jab.2014.04.001" target="_blank" >http://dx.doi.org/10.1016/j.jab.2014.04.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jab.2014.04.001" target="_blank" >10.1016/j.jab.2014.04.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acute methanol poisonings: Folates administration and visual sequelae

Popis výsledku v původním jazyce

During the outbreak of methanol poisonings in the Czech Republic 2012, we studied the clinical effectiveness of folate therapy in preventing visual damage. Data were obtained from a combined prospective and retrospective study on 79 patients: folinic acid was administered in 28, folic acid in 35; 16 patients received no folates. The groups were comparable by age, time to treatment, laboratory findings, symptoms, and treatment. The number of patients with visual sequelae differed neither between the groups treated with folinic/folic acid, nor between the groups with/without folate administration. The patients with visual sequelae were more acidotic and differed in pH, HCO3-, base deficit, anion gap, but not in methanol, ethanol, osmolal gap, formate, and pCO(2). Serum lactate, but not formate differed significantly. The higher serum glucose on admission was in the patients with visual sequelae. Regardless the rationale for folate administration in acute methanol poisoning, its clinical

Název v anglickém jazyce

Acute methanol poisonings: Folates administration and visual sequelae

Popis výsledku anglicky

During the outbreak of methanol poisonings in the Czech Republic 2012, we studied the clinical effectiveness of folate therapy in preventing visual damage. Data were obtained from a combined prospective and retrospective study on 79 patients: folinic acid was administered in 28, folic acid in 35; 16 patients received no folates. The groups were comparable by age, time to treatment, laboratory findings, symptoms, and treatment. The number of patients with visual sequelae differed neither between the groups treated with folinic/folic acid, nor between the groups with/without folate administration. The patients with visual sequelae were more acidotic and differed in pH, HCO3-, base deficit, anion gap, but not in methanol, ethanol, osmolal gap, formate, and pCO(2). Serum lactate, but not formate differed significantly. The higher serum glucose on admission was in the patients with visual sequelae. Regardless the rationale for folate administration in acute methanol poisoning, its clinical

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

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Svazek periodika

12

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

309-316

Kód UT WoS článku

000345065200016

EID výsledku v databázi Scopus

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