Analysis of serum anion gap and osmolal gap in diagnosis and prognosis of acute methanol poisoning: clinical study in 86 patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295078" target="_blank" >RIV/00216208:11110/15:10295078 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388955:_____/15:00443514 RIV/00064165:_____/15:10295078

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00706-014-1374-7" target="_blank" >http://dx.doi.org/10.1007/s00706-014-1374-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-014-1374-7" target="_blank" >10.1007/s00706-014-1374-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of serum anion gap and osmolal gap in diagnosis and prognosis of acute methanol poisoning: clinical study in 86 patients

Popis výsledku v původním jazyce

We performed a retrospective study in 86 patients from the Czech methanol outbreak in 2012 to determine the role of anion and osmolal gaps in diagnosis and prognosis of methanol poisoning. Methanol and ethanol were measured by a gas chromatographic method with flame ionization detection. Formate was measured enzymatically. Osmolality was measured by freezing point depression method. From 86 patients, 15 died, 47 survived without, and 24 survived with visual/CNS sequelae. There was a statistically significant correlation between the osmolal gap and serum methanol concentrations (R (2) = 0.704; p < 0.001); however, the sensitivity was low for the detection of serum methanol under 20 mmol dm(-3). The survivors without sequelae had lower osmolal gap than those who survived with visual/CNS damage (p = 0.002). The correlation between the anion gap and serum formate on admission was significant (R (2) = 0.28; p < 0.05). The anion gap well correlated with the variables characterizing the sever

Název v anglickém jazyce

Analysis of serum anion gap and osmolal gap in diagnosis and prognosis of acute methanol poisoning: clinical study in 86 patients

Popis výsledku anglicky

We performed a retrospective study in 86 patients from the Czech methanol outbreak in 2012 to determine the role of anion and osmolal gaps in diagnosis and prognosis of methanol poisoning. Methanol and ethanol were measured by a gas chromatographic method with flame ionization detection. Formate was measured enzymatically. Osmolality was measured by freezing point depression method. From 86 patients, 15 died, 47 survived without, and 24 survived with visual/CNS sequelae. There was a statistically significant correlation between the osmolal gap and serum methanol concentrations (R (2) = 0.704; p < 0.001); however, the sensitivity was low for the detection of serum methanol under 20 mmol dm(-3). The survivors without sequelae had lower osmolal gap than those who survived with visual/CNS damage (p = 0.002). The correlation between the anion gap and serum formate on admission was significant (R (2) = 0.28; p < 0.05). The anion gap well correlated with the variables characterizing the sever

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

—

Projekt

<a href="/cs/project/GAP208%2F12%2F1645" target="_blank" >GAP208/12/1645: Aspekty transportu rizikových kovů přes biologické membrány</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte für Chemie

ISSN

0026-9247

e-ISSN

—

Svazek periodika

146

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

8

Strana od-do

787-794

Kód UT WoS článku

000353219700008

EID výsledku v databázi Scopus

2-s2.0-84939952847