What are the implications of human papillomavirus status in oropharyngeal tumors for clinical practice?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10288150" target="_blank" >RIV/00216208:11110/14:10288150 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/14:10288150 RIV/00023736:_____/14:00011026

Výsledek na webu

<a href="http://dx.doi.org/10.1097/MOO.0000000000000030" target="_blank" >http://dx.doi.org/10.1097/MOO.0000000000000030</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MOO.0000000000000030" target="_blank" >10.1097/MOO.0000000000000030</a>

Jazyk výsledku

angličtina

Název v původním jazyce

What are the implications of human papillomavirus status in oropharyngeal tumors for clinical practice?

Popis výsledku v původním jazyce

Purpose of reviewHuman papillomavirus (HPV) status itself is an important and very probably the strongest prognostic factor in head and neck cancer. Because of the prognostic advantage of patients with HPV-positive cancers, the issue of the quality of life of survivors has become increasingly important. The possibility of treatment de-escalation in patients with virally induced tumors is being considered. Many challenges have to be addressed in order to integrate HPV status in the routine decision-making in patients with oropharyngeal cancer. The present review discusses the standardization of detection methods suitable for clinical use and the differences in predictive parameters between patients with HPV-positive and HPV-negative tumors.Recent findingsThe gold standard for the identification of patients with oropharyngeal tumors etiologically linked to HPV infection is undoubtedly the detection of HPV 16 E6/E7 mRNA. The detection of a surrogate marker of active viral infection, p16in

Název v anglickém jazyce

What are the implications of human papillomavirus status in oropharyngeal tumors for clinical practice?

Popis výsledku anglicky

Purpose of reviewHuman papillomavirus (HPV) status itself is an important and very probably the strongest prognostic factor in head and neck cancer. Because of the prognostic advantage of patients with HPV-positive cancers, the issue of the quality of life of survivors has become increasingly important. The possibility of treatment de-escalation in patients with virally induced tumors is being considered. Many challenges have to be addressed in order to integrate HPV status in the routine decision-making in patients with oropharyngeal cancer. The present review discusses the standardization of detection methods suitable for clinical use and the differences in predictive parameters between patients with HPV-positive and HPV-negative tumors.Recent findingsThe gold standard for the identification of patients with oropharyngeal tumors etiologically linked to HPV infection is undoubtedly the detection of HPV 16 E6/E7 mRNA. The detection of a surrogate marker of active viral infection, p16in

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT12483" target="_blank" >NT12483: Vztah virové etiologie nádorů orofaryngu k úspěšnosti jednotlivých léčebných modalit</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Opinion in Otolaryngology and Head and Neck Surgery

ISSN

1068-9508

e-ISSN

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Svazek periodika

22

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

90-94

Kód UT WoS článku

000333287400002

EID výsledku v databázi Scopus

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