High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV- Positive Oral and Oropharyngeal Squamous Cell Carcinomas
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10288559" target="_blank" >RIV/00216208:11110/14:10288559 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11130/14:10288559 RIV/00064203:_____/14:10288559
Výsledek na webu
<a href="http://dx.doi.org/10.1155/2014/303929" target="_blank" >http://dx.doi.org/10.1155/2014/303929</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2014/303929" target="_blank" >10.1155/2014/303929</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV- Positive Oral and Oropharyngeal Squamous Cell Carcinomas
Popis výsledku v původním jazyce
Background. Human papillomaviruses (HPVs) have been proved as one of the etiological factors of oropharyngeal squamous cell carcinoma (OPSCC). Patients with tumors of viral etiology have a lower recurrence rate and better prognosis. OPSCC is linked to analteration in the immune system. Only a limited number of studies have correlated both the immunological parameters and HPV status with patient prognosis. The aim of this study was to determine whether HPV infection and the immunological status influence patient prognosis individually or in concurrence. Material and Methods. Sixty patients with oral and oropharyngeal carcinomas were enrolled. They were divided into HPV-positive and HPV-negative groups based on the expression of HPV 16 E6 mRNA. Basic lymphocyte subpopulations were determined in the peripheral blood by means of flow cytometry. Results. Significantly better disease-specific survival (DSS) was observed in patients with HPV-positive tumors. Nodal status, tumor grade, recurr
Název v anglickém jazyce
High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV- Positive Oral and Oropharyngeal Squamous Cell Carcinomas
Popis výsledku anglicky
Background. Human papillomaviruses (HPVs) have been proved as one of the etiological factors of oropharyngeal squamous cell carcinoma (OPSCC). Patients with tumors of viral etiology have a lower recurrence rate and better prognosis. OPSCC is linked to analteration in the immune system. Only a limited number of studies have correlated both the immunological parameters and HPV status with patient prognosis. The aim of this study was to determine whether HPV infection and the immunological status influence patient prognosis individually or in concurrence. Material and Methods. Sixty patients with oral and oropharyngeal carcinomas were enrolled. They were divided into HPV-positive and HPV-negative groups based on the expression of HPV 16 E6 mRNA. Basic lymphocyte subpopulations were determined in the peripheral blood by means of flow cytometry. Results. Significantly better disease-specific survival (DSS) was observed in patients with HPV-positive tumors. Nodal status, tumor grade, recurr
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FF - ORL, oftalmologie, stomatologie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
BioMed Research International
ISSN
2314-6133
e-ISSN
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Svazek periodika
2014
Číslo periodika v rámci svazku
April
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
11
Strana od-do
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Kód UT WoS článku
000335233200001
EID výsledku v databázi Scopus
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