Promising new treatment targets in patients with fibrosing lung disorders

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10291502" target="_blank" >RIV/00216208:11110/14:10291502 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064190:_____/14:#0000927

Výsledek na webu

<a href="http://dx.doi.org/10.12998/wjcc.v2.i11.668" target="_blank" >http://dx.doi.org/10.12998/wjcc.v2.i11.668</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.12998/wjcc.v2.i11.668" target="_blank" >10.12998/wjcc.v2.i11.668</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Promising new treatment targets in patients with fibrosing lung disorders

Popis výsledku v původním jazyce

The processes of lung fibrogenesis and fibrotic healing are common to a number of conditions with different etiologies. The lungs are the only affected organ in some cases, whereas in others, several organ systems are involved. Therapeutic options can bediscussed from various perspectives. In this review, we address the localization of therapeutic targets with regard to cell compartments, including secreted ligands, cell surface, plasma membrane-cytosol interplay, cytosol and nucleus. Complex approachusing stem cell therapy is also discussed. As the prognosis of patients with these disorders remains grim, treatment combinations targeting different molecules within the cell should sometimes be considered. It is reasonable to assume that blocking specific pathways will more likely lead to disease stabilization, while stem cell-based treatments could potentially restore lung architecture. Gene therapy could be a candidate for preventive care in families with proven specific gene polymor

Název v anglickém jazyce

Promising new treatment targets in patients with fibrosing lung disorders

Popis výsledku anglicky

The processes of lung fibrogenesis and fibrotic healing are common to a number of conditions with different etiologies. The lungs are the only affected organ in some cases, whereas in others, several organ systems are involved. Therapeutic options can bediscussed from various perspectives. In this review, we address the localization of therapeutic targets with regard to cell compartments, including secreted ligands, cell surface, plasma membrane-cytosol interplay, cytosol and nucleus. Complex approachusing stem cell therapy is also discussed. As the prognosis of patients with these disorders remains grim, treatment combinations targeting different molecules within the cell should sometimes be considered. It is reasonable to assume that blocking specific pathways will more likely lead to disease stabilization, while stem cell-based treatments could potentially restore lung architecture. Gene therapy could be a candidate for preventive care in families with proven specific gene polymor

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FC - Pneumologie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

World Journal of Clinical Cases

ISSN

2307-8960

e-ISSN

—

Svazek periodika

2

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

668-675

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—