Stem Cell Treatment in Amyotrophic Lateral Sclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F15%3A00459255" target="_blank" >RIV/68378041:_____/15:00459255 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Stem Cell Treatment in Amyotrophic Lateral Sclerosis

Popis výsledku v původním jazyce

Amyotrophic lateral sclerosis (ALS) is a largely sporadic progressive neurodegenerative disease affecting upper and lower motor neurons (MNs) and specific etiology that is not completely understood. Up to now, there is no clinically relevant treatment available for ALS. The novel therapeutic strategies should aim at neuroprotection, stimulation of intrinsic neurogenesis and replacement of affected neural cells. These could be achieved by application of powerful modern therapeutic methods such as gene therapy, transplantation of different types of engineered and non-engineered stem cells. Cell-based therapies could facilitate either restoration/substitution or the preservation of MNs. Special attention has been paid to treatment with autologous stem cells, as the most promising approach to the treatment of ALS patients. This review summarises the progress made in translating to the patients' bedside the results achieved from in vivo preclinical studies.

Název v anglickém jazyce

Stem Cell Treatment in Amyotrophic Lateral Sclerosis

Popis výsledku anglicky

Amyotrophic lateral sclerosis (ALS) is a largely sporadic progressive neurodegenerative disease affecting upper and lower motor neurons (MNs) and specific etiology that is not completely understood. Up to now, there is no clinically relevant treatment available for ALS. The novel therapeutic strategies should aim at neuroprotection, stimulation of intrinsic neurogenesis and replacement of affected neural cells. These could be achieved by application of powerful modern therapeutic methods such as gene therapy, transplantation of different types of engineered and non-engineered stem cells. Cell-based therapies could facilitate either restoration/substitution or the preservation of MNs. Special attention has been paid to treatment with autologous stem cells, as the most promising approach to the treatment of ALS patients. This review summarises the progress made in translating to the patients' bedside the results achieved from in vivo preclinical studies.

Druh

C - Kapitola v odborné knize

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/LO1309" target="_blank" >LO1309: Buněčná terapie a tkáňové náhrady</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

From Functionalized Nanostructures Towards Engineered Macrostructures

ISBN

978-80-88113-20-1

Počet stran výsledku

13

Strana od-do

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Počet stran knihy

176

Název nakladatele

Epika

Místo vydání

Jindřichův Hradec

Kód UT WoS kapitoly

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