Psychiatric disturbances in five patients with MELAS syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F14%3A10293638" target="_blank" >RIV/00216208:11110/14:10293638 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/14:10293638

Výsledek na webu

<a href="http://www.psychiatriapolska.pl/uploads/images/PP_5_2014/1035ENGverMagner_PsychiatrPol2014v48i5.pdf" target="_blank" >http://www.psychiatriapolska.pl/uploads/images/PP_5_2014/1035ENGverMagner_PsychiatrPol2014v48i5.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Psychiatric disturbances in five patients with MELAS syndrome

Popis výsledku v původním jazyce

Objectives: Mitochondrial disorders of energetic metabolism (MD) represent a heterogeneous group of diseases manifesting at any age with a broad spectrum of clinical symptoms, including psychiatric disorders. Methods: The aim of the study was to characterize psychiatric symptoms and diagnoses in five patients with MELAS syndrome between the ages of 17 and 53 years. Results: Four of MELAS patients them harbored the prevalent mitochondrial DNA (mtDNA) mutation 3243A>G, and one patient had the mtDNA mutation 12706T>C. Three patients had positive family histories for MELAS syndrome. In one patient, depression was diagnosed as the first symptom of MELAS syndrome. Depression also preceded a stroke-like episode in one patient. Four patients had disturbed cognitive functions, confusional states occurred in three patients. One patient manifested psychotic (schizophrenia-like) symptoms. Conclusion: Mitochondrial disorders deserve consideration as part of the differential diagnosis, especially if

Název v anglickém jazyce

Psychiatric disturbances in five patients with MELAS syndrome

Popis výsledku anglicky

Objectives: Mitochondrial disorders of energetic metabolism (MD) represent a heterogeneous group of diseases manifesting at any age with a broad spectrum of clinical symptoms, including psychiatric disorders. Methods: The aim of the study was to characterize psychiatric symptoms and diagnoses in five patients with MELAS syndrome between the ages of 17 and 53 years. Results: Four of MELAS patients them harbored the prevalent mitochondrial DNA (mtDNA) mutation 3243A>G, and one patient had the mtDNA mutation 12706T>C. Three patients had positive family histories for MELAS syndrome. In one patient, depression was diagnosed as the first symptom of MELAS syndrome. Depression also preceded a stroke-like episode in one patient. Four patients had disturbed cognitive functions, confusional states occurred in three patients. One patient manifested psychotic (schizophrenia-like) symptoms. Conclusion: Mitochondrial disorders deserve consideration as part of the differential diagnosis, especially if

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FG - Pediatrie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14156" target="_blank" >NT14156: Nové algoritmy v diagnostice mitochondriálních poruch u dětí</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychiatria Polska

ISSN

0033-2674

e-ISSN

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Svazek periodika

48

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

11

Strana od-do

1035-1045

Kód UT WoS článku

000346596500013

EID výsledku v databázi Scopus

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