Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10282812" target="_blank" >RIV/00216208:11110/15:10282812 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023001:_____/15:00059327 RIV/00064165:_____/15:10282812

Výsledek na webu

<a href="http://dx.doi.org/10.1097/HJH.0000000000000464" target="_blank" >http://dx.doi.org/10.1097/HJH.0000000000000464</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/HJH.0000000000000464" target="_blank" >10.1097/HJH.0000000000000464</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness

Popis výsledku v původním jazyce

Background: Aldosterone has been shown to substantially contribute to the accumulation of different types of collagen fibres and growth factors in the arterial wall, thus increasing wall thickness. A previous study showed reduction of increased common carotid intima-media thickness (IMT) in patients with primary aldosteronism 1 year after adrenalectomy. Our study in patients with primary aldosteronism was aimed at comparing the long-term effect of adrenalectomy vs. spironolactone therapy on common carotid IMT regression. Method: Forty-two patients with confirmed primary aldosteronism (21 with aldosterone-producing adenoma treated by unilateral laparoscopic adrenalectomy, 21 treated with spironolactone) were investigated by carotid ultrasound at baseline and 1 and 6 years after the specific treatment. Results: There was a decrease in common carotid IMT from 0.956 +/- 0.140 to 0.900 +/- 0.127 mm (-5.9%; P < 0.05) at 1 year and to 0.866 +/- 0.130 mm (-9.4%; P < 0.01) at 6 years after adre

Název v anglickém jazyce

Long-term effect of specific treatment of primary aldosteronism on carotid intima-media thickness

Popis výsledku anglicky

Background: Aldosterone has been shown to substantially contribute to the accumulation of different types of collagen fibres and growth factors in the arterial wall, thus increasing wall thickness. A previous study showed reduction of increased common carotid intima-media thickness (IMT) in patients with primary aldosteronism 1 year after adrenalectomy. Our study in patients with primary aldosteronism was aimed at comparing the long-term effect of adrenalectomy vs. spironolactone therapy on common carotid IMT regression. Method: Forty-two patients with confirmed primary aldosteronism (21 with aldosterone-producing adenoma treated by unilateral laparoscopic adrenalectomy, 21 treated with spironolactone) were investigated by carotid ultrasound at baseline and 1 and 6 years after the specific treatment. Results: There was a decrease in common carotid IMT from 0.956 +/- 0.140 to 0.900 +/- 0.127 mm (-5.9%; P < 0.05) at 1 year and to 0.866 +/- 0.130 mm (-9.4%; P < 0.01) at 6 years after adre

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT14155" target="_blank" >NT14155: Vliv specifické léčby primárního hyperaldosteronismu na ústup subklinického orgánového poškození</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Hypertension

ISSN

0263-6352

e-ISSN

—

Svazek periodika

33

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

874-882

Kód UT WoS článku

000351956700029

EID výsledku v databázi Scopus

2-s2.0-84938998959