The protective effect of hypercapnia on ischemia-reperfusion injury in lungs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294595" target="_blank" >RIV/00216208:11110/15:10294595 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/15:10294595 RIV/00064203:_____/15:10294595

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.resp.2014.10.002" target="_blank" >http://dx.doi.org/10.1016/j.resp.2014.10.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.resp.2014.10.002" target="_blank" >10.1016/j.resp.2014.10.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The protective effect of hypercapnia on ischemia-reperfusion injury in lungs

Popis výsledku v původním jazyce

Lifesaving therapy for patients with end-stage lung disease is lung transplantation. However, there are not enough available donors. A relatively new method of transplantation from non-heart-beating donors (NHBDs) allows the treatment of the lung outsidethe body and could increase the number of suitable lungs. We have focused on hypercapnic ventilation, which has the possibility of reducing reactive oxygen species damage. We used four experimental and two control groups of adult rats. Each experimentalgroup underwent the protocol of NHBD lung harvesting. The lungs were than perfused in an ex vivo model and we measured weight gain, arterial-venous difference in partial pressure of oxygen and perfusion pressure. We observed that hypercapnic ventilationduring reperfusion reduces the development of pulmonary oedema and has a protective effect on the oxygen transport ability of the lungs after warm ischemia. The effect of CO2 on pulmonary oedema and on oxygen transport ability after warm

Název v anglickém jazyce

The protective effect of hypercapnia on ischemia-reperfusion injury in lungs

Popis výsledku anglicky

Lifesaving therapy for patients with end-stage lung disease is lung transplantation. However, there are not enough available donors. A relatively new method of transplantation from non-heart-beating donors (NHBDs) allows the treatment of the lung outsidethe body and could increase the number of suitable lungs. We have focused on hypercapnic ventilation, which has the possibility of reducing reactive oxygen species damage. We used four experimental and two control groups of adult rats. Each experimentalgroup underwent the protocol of NHBD lung harvesting. The lungs were than perfused in an ex vivo model and we measured weight gain, arterial-venous difference in partial pressure of oxygen and perfusion pressure. We observed that hypercapnic ventilationduring reperfusion reduces the development of pulmonary oedema and has a protective effect on the oxygen transport ability of the lungs after warm ischemia. The effect of CO2 on pulmonary oedema and on oxygen transport ability after warm

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Respiratory Physiology and Neurobiology

ISSN

1569-9048

e-ISSN

—

Svazek periodika

205

Číslo periodika v rámci svazku

leden

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

42-46

Kód UT WoS článku

000347654800007

EID výsledku v databázi Scopus

2-s2.0-84910072764