Chronic stress-like syndrome as a consequence of medial site subthalamic stimulation in Parkinson's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294720" target="_blank" >RIV/00216208:11110/15:10294720 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/15:10294720

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.psyneuen.2014.12.001" target="_blank" >http://dx.doi.org/10.1016/j.psyneuen.2014.12.001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.psyneuen.2014.12.001" target="_blank" >10.1016/j.psyneuen.2014.12.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chronic stress-like syndrome as a consequence of medial site subthalamic stimulation in Parkinson's disease

Popis výsledku v původním jazyce

Considering the functional organization of the subthalamic nucleus (STN), we hypothesized that subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease might have a differential impact on the hypothalamic-pituitary-adrenal axis in relation tothe position of active stimulating contact within the STN. In addition, we searched for any STN-DBS-related morning plasma cortisol changes in association with postoperative anxiety and weight gain. A plasma cortisol measurement was performed on the dayof initiation of bilateral STN-DBS and repeated after 1 and 17 months in twenty patients with advanced Parkinson's disease. The body weight change and anxiety scores following the implantation were assessed as well. The electrode positions in the STN were determined on T1-weighted magnetic resonance images. After initiation of stimulation, cortisol levels significantly decreased and the cortisol changes after 1 and 17 months strongly correlated with the position of active contact in the

Název v anglickém jazyce

Chronic stress-like syndrome as a consequence of medial site subthalamic stimulation in Parkinson's disease

Popis výsledku anglicky

Considering the functional organization of the subthalamic nucleus (STN), we hypothesized that subthalamic deep brain stimulation (STN-DBS) in Parkinson's disease might have a differential impact on the hypothalamic-pituitary-adrenal axis in relation tothe position of active stimulating contact within the STN. In addition, we searched for any STN-DBS-related morning plasma cortisol changes in association with postoperative anxiety and weight gain. A plasma cortisol measurement was performed on the dayof initiation of bilateral STN-DBS and repeated after 1 and 17 months in twenty patients with advanced Parkinson's disease. The body weight change and anxiety scores following the implantation were assessed as well. The electrode positions in the STN were determined on T1-weighted magnetic resonance images. After initiation of stimulation, cortisol levels significantly decreased and the cortisol changes after 1 and 17 months strongly correlated with the position of active contact in the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Psychoneuroendocrinology

ISSN

0306-4530

e-ISSN

—

Svazek periodika

52

Číslo periodika v rámci svazku

February

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

302-310

Kód UT WoS článku

000349271000029

EID výsledku v databázi Scopus

2-s2.0-84922649660