Distinct populations of neurons respond to emotional valence and arousal in the human subthalamic nucleus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294795" target="_blank" >RIV/00216208:11110/15:10294795 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/15:00226868 RIV/00064165:_____/15:10294795

Výsledek na webu

<a href="http://dx.doi.org/10.1073/pnas.1410709112" target="_blank" >http://dx.doi.org/10.1073/pnas.1410709112</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1073/pnas.1410709112" target="_blank" >10.1073/pnas.1410709112</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Distinct populations of neurons respond to emotional valence and arousal in the human subthalamic nucleus

Popis výsledku v původním jazyce

Both animal studies and studies using deep brain stimulation in humans have demonstrated the involvement of the subthalamic nucleus (STN) in motivational and emotional processes; however, participation of this nucleus in processing human emotion has notbeen investigated directly at the single- neuron level. We analyzed the relationship between the neuronal firing from intraoperative microrecordings from the STN during affective picture presentation in patients with Parkinson's disease (PD) and the affective ratings of emotional valence and arousal performed subsequently. We observed that 17% of neurons responded to emotional valence and arousal of visual stimuli according to individual ratings. The activity of some neurons was related to emotional valence, whereas different neurons responded to arousal. In addition, 14% of neurons responded to visual stimuli. Our results suggest the existence of neurons involved in processing or transmission of visual and emotional information in the

Název v anglickém jazyce

Distinct populations of neurons respond to emotional valence and arousal in the human subthalamic nucleus

Popis výsledku anglicky

Both animal studies and studies using deep brain stimulation in humans have demonstrated the involvement of the subthalamic nucleus (STN) in motivational and emotional processes; however, participation of this nucleus in processing human emotion has notbeen investigated directly at the single- neuron level. We analyzed the relationship between the neuronal firing from intraoperative microrecordings from the STN during affective picture presentation in patients with Parkinson's disease (PD) and the affective ratings of emotional valence and arousal performed subsequently. We observed that 17% of neurons responded to emotional valence and arousal of visual stimuli according to individual ratings. The activity of some neurons was related to emotional valence, whereas different neurons responded to arousal. In addition, 14% of neurons responded to visual stimuli. Our results suggest the existence of neurons involved in processing or transmission of visual and emotional information in the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Proceedings of the National Academy of Sciences of the United States of America

ISSN

0027-8424

e-ISSN

—

Svazek periodika

112

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

3116-3121

Kód UT WoS článku

000350646500057

EID výsledku v databázi Scopus

2-s2.0-84924322553