Gradient-like organization of the subthalamic nucleus with respect to emotional arousal: a neuroanatomical study with deep brain stimulation in Parkinson's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F15%3A00237356" target="_blank" >RIV/68407700:21230/15:00237356 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/ene.12807/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/ene.12807/pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Gradient-like organization of the subthalamic nucleus with respect to emotional arousal: a neuroanatomical study with deep brain stimulation in Parkinson's disease

Popis výsledku v původním jazyce

Background and aims: Changes in emotional processes have been reported after subthalamic deep brain stimulation (STN-DBS) in Parkinsons disease (PD). Considering the functional organization of the subthalamic nucleus (STN), we hypothesized that STN-DBS might have a differential impact on subjective experience of emotional valence (un-pleasantness/pleasantness) and arousal to affective stimuli in relation to the electrode position within the STN. Methods: 20 PD patients (all men; off-medication) viewed pictures depicting primary rewarding (erotica and food), aversive fearful or neutral stimuli and performed ratings according to emotional valence and arousal in STN-DBS switched ON- and OFF-conditions. The active electrode contact positions in the STN were determined on T1-weighted MRI. The ON vs. OFF ratings differences and their relation to the active contact positions were assessed using linear models. Results: In the DBS ON-condition, patients attributed lo-wer valence scores to the a

Název v anglickém jazyce

Gradient-like organization of the subthalamic nucleus with respect to emotional arousal: a neuroanatomical study with deep brain stimulation in Parkinson's disease

Popis výsledku anglicky

Background and aims: Changes in emotional processes have been reported after subthalamic deep brain stimulation (STN-DBS) in Parkinsons disease (PD). Considering the functional organization of the subthalamic nucleus (STN), we hypothesized that STN-DBS might have a differential impact on subjective experience of emotional valence (un-pleasantness/pleasantness) and arousal to affective stimuli in relation to the electrode position within the STN. Methods: 20 PD patients (all men; off-medication) viewed pictures depicting primary rewarding (erotica and food), aversive fearful or neutral stimuli and performed ratings according to emotional valence and arousal in STN-DBS switched ON- and OFF-conditions. The active electrode contact positions in the STN were determined on T1-weighted MRI. The ON vs. OFF ratings differences and their relation to the active contact positions were assessed using linear models. Results: In the DBS ON-condition, patients attributed lo-wer valence scores to the a

Druh

O - Ostatní výsledky

CEP obor

JC - Počítačový hardware a software

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů