Emotional valence and arousal gradient along the anterior-posterior axis within the subthalamic nucleus in Parkinson's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68407700%3A21230%2F16%3A00307361" target="_blank" >RIV/68407700:21230/16:00307361 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.clinph-journal.com/article/S1388-2457(16)30293-0/abstract" target="_blank" >http://www.clinph-journal.com/article/S1388-2457(16)30293-0/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinph.2016.05.237" target="_blank" >10.1016/j.clinph.2016.05.237</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Emotional valence and arousal gradient along the anterior-posterior axis within the subthalamic nucleus in Parkinson's disease

Popis výsledku v původním jazyce

Changes in emotional processes have been reported after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson’s disease (PD). The STN DBS increased activity of the aversive motivational system: the fearful stimuli were experienced as more salient with the DBS switched on. The STN is organized into a dorsolateral motor, a central associative, and a ventromedial limbic territories and clinical effects of STN DBS seem to depend on the position of the active electrode contact within the STN in a manner that reflects the functional organization and connectivity of the STN. Considering the functional organization of the STN, we aimed to analyze the relationship between changes in subjective emotional experience to pictures presenting fearful stimuli and the active electrode contact position within the STN. Our results confirm previous observations STN DBS affects emotional processing related to aversive stimuli. They further suggest emotional valence and arousal are processed separately at this subcortical level and their representations are organized along the anterior–posterior axis in the STN.

Název v anglickém jazyce

Emotional valence and arousal gradient along the anterior-posterior axis within the subthalamic nucleus in Parkinson's disease

Popis výsledku anglicky

Changes in emotional processes have been reported after deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson’s disease (PD). The STN DBS increased activity of the aversive motivational system: the fearful stimuli were experienced as more salient with the DBS switched on. The STN is organized into a dorsolateral motor, a central associative, and a ventromedial limbic territories and clinical effects of STN DBS seem to depend on the position of the active electrode contact within the STN in a manner that reflects the functional organization and connectivity of the STN. Considering the functional organization of the STN, we aimed to analyze the relationship between changes in subjective emotional experience to pictures presenting fearful stimuli and the active electrode contact position within the STN. Our results confirm previous observations STN DBS affects emotional processing related to aversive stimuli. They further suggest emotional valence and arousal are processed separately at this subcortical level and their representations are organized along the anterior–posterior axis in the STN.

Druh

O - Ostatní výsledky

CEP obor

JD - Využití počítačů, robotika a její aplikace

OECD FORD obor

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Projekt

<a href="/cs/project/GA16-13323S" target="_blank" >GA16-13323S: Mikro a makro konektomika subtalamického jádra u člověka: vliv neuromodulace a dopaminové deplece</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů