Inducibility of ventricular fibrillation during mild therapeutic hypothermia: electrophysiological study in a swine model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294800" target="_blank" >RIV/00216208:11110/15:10294800 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/15:10294800

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s12967-015-0429-9" target="_blank" >http://dx.doi.org/10.1186/s12967-015-0429-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12967-015-0429-9" target="_blank" >10.1186/s12967-015-0429-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Inducibility of ventricular fibrillation during mild therapeutic hypothermia: electrophysiological study in a swine model

Popis výsledku v původním jazyce

Mild therapeutic hypothermia (MTH) is being used after cardiac arrest for its expected improvement in neurological outcome. Safety of MTH concerning inducibility of malignant arrhythmias has not been satisfactorily demonstrated. This study compares inducibility of ventricular fibrillation (VF) before and after induction of MTH in a whole body swine model and evaluates possible interaction with changing potassium plasma levels. Methods: The extracorporeal cooling was introduced in fully anesthetized swine (n = 6) to provide MTH. Inducibility of VF was studied by programmed ventricular stimulation three times in each animal under the following: during normothermia (NT), after reaching the core temperature of 32 degrees C (HT) and after another 60 minutesof stable hypothermia (HT60). Inducibility of VF, effective refractory period of the ventricles (ERP), QTc interval and potassium plasma levels were measured. Results: Starting at normothermia of 38.7 (IQR 38.2; 39.8)degrees C, HT was ac

Název v anglickém jazyce

Inducibility of ventricular fibrillation during mild therapeutic hypothermia: electrophysiological study in a swine model

Popis výsledku anglicky

Mild therapeutic hypothermia (MTH) is being used after cardiac arrest for its expected improvement in neurological outcome. Safety of MTH concerning inducibility of malignant arrhythmias has not been satisfactorily demonstrated. This study compares inducibility of ventricular fibrillation (VF) before and after induction of MTH in a whole body swine model and evaluates possible interaction with changing potassium plasma levels. Methods: The extracorporeal cooling was introduced in fully anesthetized swine (n = 6) to provide MTH. Inducibility of VF was studied by programmed ventricular stimulation three times in each animal under the following: during normothermia (NT), after reaching the core temperature of 32 degrees C (HT) and after another 60 minutesof stable hypothermia (HT60). Inducibility of VF, effective refractory period of the ventricles (ERP), QTc interval and potassium plasma levels were measured. Results: Starting at normothermia of 38.7 (IQR 38.2; 39.8)degrees C, HT was ac

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

<a href="/cs/project/NT14160" target="_blank" >NT14160: Restenózy dialyzačních cévních zkratů: jejich kvantifikace, pochopení etiologie a efektivita moderní perkutánní léčby</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Translational Medicine

ISSN

1479-5876

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

February

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

—

Kód UT WoS článku

000350508600002

EID výsledku v databázi Scopus

2-s2.0-84924303292