Effect of Occupational Exposures on Lung Cancer Susceptibility: A Study of Gene-Environment Interaction Analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10294931" target="_blank" >RIV/00216208:11110/15:10294931 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/15:00087034 RIV/61989592:15110/15:33154950 RIV/00209805:_____/15:#0000696

Výsledek na webu

<a href="http://dx.doi.org/10.1158/1055-9965.EPI-14-1143-T" target="_blank" >http://dx.doi.org/10.1158/1055-9965.EPI-14-1143-T</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1158/1055-9965.EPI-14-1143-T" target="_blank" >10.1158/1055-9965.EPI-14-1143-T</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of Occupational Exposures on Lung Cancer Susceptibility: A Study of Gene-Environment Interaction Analysis

Popis výsledku v původním jazyce

Background: Occupational exposures are known risk factors for lung cancer. Role of genetically determined host factors in occupational exposure-related lung cancer is unclear. Methods: We used genome-wide association (GWA) data from a case-control studyconducted in 6 European countries from 1998 to 2002 to identify gene-occupation interactions and related pathways for lung cancer risk. GWA analysis was performed for each exposure using logistic regression and interaction term for genotypes, and exposure was included in this model. Both SNP-based and gene-based interaction P values were calculated. Pathway analysis was performed using three complementary methods, and analyses were adjusted for multiple comparisons. We analyzed 312,605 SNPs and occupational exposure to 70 agents from 1,802 lung cancer cases and 1,725 cancer-free controls. Results: Mean age of study participants was 60.1 +/- 9.1 years and 75% were male. Largest number of significant associations (P <= 1 x 10(-5)) at SNP

Název v anglickém jazyce

Effect of Occupational Exposures on Lung Cancer Susceptibility: A Study of Gene-Environment Interaction Analysis

Popis výsledku anglicky

Background: Occupational exposures are known risk factors for lung cancer. Role of genetically determined host factors in occupational exposure-related lung cancer is unclear. Methods: We used genome-wide association (GWA) data from a case-control studyconducted in 6 European countries from 1998 to 2002 to identify gene-occupation interactions and related pathways for lung cancer risk. GWA analysis was performed for each exposure using logistic regression and interaction term for genotypes, and exposure was included in this model. Both SNP-based and gene-based interaction P values were calculated. Pathway analysis was performed using three complementary methods, and analyses were adjusted for multiple comparisons. We analyzed 312,605 SNPs and occupational exposure to 70 agents from 1,802 lung cancer cases and 1,725 cancer-free controls. Results: Mean age of study participants was 60.1 +/- 9.1 years and 75% were male. Largest number of significant associations (P <= 1 x 10(-5)) at SNP

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FQ - Veřejné zdravotnictví, sociální lékařství

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cancer Epidemiology Biomarkers and Prevention

ISSN

1055-9965

e-ISSN

—

Svazek periodika

24

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

570-579

Kód UT WoS článku

000351953100013

EID výsledku v databázi Scopus

2-s2.0-84927761476