Comparability of patients with ANCA-associated vasculitis enrolled in clinical trials or in observational cohorts

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295615" target="_blank" >RIV/00216208:11110/15:10295615 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/15:10295615

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Comparability of patients with ANCA-associated vasculitis enrolled in clinical trials or in observational cohorts

Popis výsledku v původním jazyce

Objective. To analyse the differences between patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) entered into randomised clinical trials (RCTs) and those followed in large observational cohorts. Methods. The main characteristics and outcomes of patients with generalised and/or severe GPA or MPA with a fivefactor score >= 1 enrolled in the French Vasculitis Study Group (FVSG) or the US-Canadian-based Vasculitis Clinical Research Consortium cohorts were compared to those enrolled in one of 2 FVSG clinical RCTs (WEG91, WE-GENT) or 3 European Vasculitis Society clinical trials (CYCLOPS, CYCAZAREM, IMPROVE). Results. 657 patients (653% with GPA) in RCTs were compared to 437 in cohorts (90.6% with GPA). RCT patients were older at diagnosis than the cohort patients (56.6 +/- 13.9 vs. 46.8 +/- 17.3 years), had higher Birmingham vasculitis activity score (19.5 +/- 9.1 vs. 16.9 +/- 7.4), and more frequent kidney disease (84.0% vs. 54.9%) but fewer ear, nose, a

Název v anglickém jazyce

Comparability of patients with ANCA-associated vasculitis enrolled in clinical trials or in observational cohorts

Popis výsledku anglicky

Objective. To analyse the differences between patients with granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) entered into randomised clinical trials (RCTs) and those followed in large observational cohorts. Methods. The main characteristics and outcomes of patients with generalised and/or severe GPA or MPA with a fivefactor score >= 1 enrolled in the French Vasculitis Study Group (FVSG) or the US-Canadian-based Vasculitis Clinical Research Consortium cohorts were compared to those enrolled in one of 2 FVSG clinical RCTs (WEG91, WE-GENT) or 3 European Vasculitis Society clinical trials (CYCLOPS, CYCAZAREM, IMPROVE). Results. 657 patients (653% with GPA) in RCTs were compared to 437 in cohorts (90.6% with GPA). RCT patients were older at diagnosis than the cohort patients (56.6 +/- 13.9 vs. 46.8 +/- 17.3 years), had higher Birmingham vasculitis activity score (19.5 +/- 9.1 vs. 16.9 +/- 7.4), and more frequent kidney disease (84.0% vs. 54.9%) but fewer ear, nose, a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical and Experimental Rheumatology

ISSN

0392-856X

e-ISSN

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Svazek periodika

33

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

7

Strana od-do

"S77"-"S83"

Kód UT WoS článku

000356402900013

EID výsledku v databázi Scopus

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