A 40-bp VNTR polymorphism in the 3 '-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295617" target="_blank" >RIV/00216208:11110/15:10295617 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/15:00445121 RIV/00216224:14310/15:00087478 RIV/00064165:_____/15:10295617

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s12993-015-0066-8" target="_blank" >http://dx.doi.org/10.1186/s12993-015-0066-8</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12993-015-0066-8" target="_blank" >10.1186/s12993-015-0066-8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A 40-bp VNTR polymorphism in the 3 '-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism

Popis výsledku v původním jazyce

Background: ADHD and alcoholism are psychiatric diseases with pathophysiology related to dopamine system. DAT1 belongs to the SLC6 family of transporters and is involved in the regulation of extracellular dopamine levels. A 40 bp variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1/SLC6A3 gene was previously reported to be associated with various phenotypes involving disturbed regulation of dopaminergic neurotransmission. Methods: A total of 1312 subjects were includedand genotyped for 40 bp VNTR polymorphism of DAT1/SLC6A3 gene in this study (441 alcoholics, 400 non-alcoholic controls, 218 ADHD children and 253 non ADHD children). Using miRBase software, we have performed a computer analysis of VNTR part of DAT1 gene for presence of miRNA binding sites. Results: We have found significant relationships between ADHD and the 40 bp VNTR polymorphisms of DAT1/SLC6A3 gene (P < 0.01). The 9/9 genotype appeared to reduce the risk of ADHD about 0.4-fold (p <

Název v anglickém jazyce

A 40-bp VNTR polymorphism in the 3 '-untranslated region of DAT1/SLC6A3 is associated with ADHD but not with alcoholism

Popis výsledku anglicky

Background: ADHD and alcoholism are psychiatric diseases with pathophysiology related to dopamine system. DAT1 belongs to the SLC6 family of transporters and is involved in the regulation of extracellular dopamine levels. A 40 bp variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1/SLC6A3 gene was previously reported to be associated with various phenotypes involving disturbed regulation of dopaminergic neurotransmission. Methods: A total of 1312 subjects were includedand genotyped for 40 bp VNTR polymorphism of DAT1/SLC6A3 gene in this study (441 alcoholics, 400 non-alcoholic controls, 218 ADHD children and 253 non ADHD children). Using miRBase software, we have performed a computer analysis of VNTR part of DAT1 gene for presence of miRNA binding sites. Results: We have found significant relationships between ADHD and the 40 bp VNTR polymorphisms of DAT1/SLC6A3 gene (P < 0.01). The 9/9 genotype appeared to reduce the risk of ADHD about 0.4-fold (p <

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FL - Psychiatrie, sexuologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Behavioral and Brain Functions

ISSN

1744-9081

e-ISSN

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Svazek periodika

11

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000356474900001

EID výsledku v databázi Scopus

2-s2.0-84935889527