Stable polymersomes based on ionic-zwitterionic block copolymers modified with superparamagnetic iron oxide nanoparticles for biomedical applications
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10295687" target="_blank" >RIV/00216208:11110/15:10295687 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1039/c5tb00182j" target="_blank" >http://dx.doi.org/10.1039/c5tb00182j</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c5tb00182j" target="_blank" >10.1039/c5tb00182j</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Stable polymersomes based on ionic-zwitterionic block copolymers modified with superparamagnetic iron oxide nanoparticles for biomedical applications
Popis výsledku v původním jazyce
Stable polymersomes with semipermeable membranes were prepared by simple mixing of two oppositely charged diblock copolymers containing zwitterionic and cationic (PMPC20-b-PMAPTAC(190)) or anionic (PMPC20-b-PAMPS(196)) blocks. The formation of vesicularstructures in the mixed solution of the block copolymers was confirmed by direct observation using the cryo-TEM technique. Superparamagnetic iron oxide nanoparticles coated with a cationic chitosan derivative (SPION/CCh) and decorated with a fluorescentprobe molecule were next incorporated into the polymersome structure. The average diameter of SPION/CCh-polymersomes estimated using cryo-TEM was about 250 nm. Surface topography of the SPION/CCh-loaded vesicles was imaged using AFM and the magnetic properties of these objects were confirmed by MFM and MRI measurements. The ability of SPION/CCh-polymersomes to affect T-2 relaxation time in MRI was evaluated based on the measurements of r(2) relaxivity. The obtained value of r(2) (573 +/-
Název v anglickém jazyce
Stable polymersomes based on ionic-zwitterionic block copolymers modified with superparamagnetic iron oxide nanoparticles for biomedical applications
Popis výsledku anglicky
Stable polymersomes with semipermeable membranes were prepared by simple mixing of two oppositely charged diblock copolymers containing zwitterionic and cationic (PMPC20-b-PMAPTAC(190)) or anionic (PMPC20-b-PAMPS(196)) blocks. The formation of vesicularstructures in the mixed solution of the block copolymers was confirmed by direct observation using the cryo-TEM technique. Superparamagnetic iron oxide nanoparticles coated with a cationic chitosan derivative (SPION/CCh) and decorated with a fluorescentprobe molecule were next incorporated into the polymersome structure. The average diameter of SPION/CCh-polymersomes estimated using cryo-TEM was about 250 nm. Surface topography of the SPION/CCh-loaded vesicles was imaged using AFM and the magnetic properties of these objects were confirmed by MFM and MRI measurements. The ability of SPION/CCh-polymersomes to affect T-2 relaxation time in MRI was evaluated based on the measurements of r(2) relaxivity. The obtained value of r(2) (573 +/-
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EA - Morfologické obory a cytologie
OECD FORD obor
—
Návaznosti výsledku
Projekt
<a href="/cs/project/GBP302%2F12%2FG157" target="_blank" >GBP302/12/G157: Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Materials Chemistry B
ISSN
2050-750X
e-ISSN
—
Svazek periodika
3
Číslo periodika v rámci svazku
27
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
9
Strana od-do
5523-5531
Kód UT WoS článku
000357180400013
EID výsledku v databázi Scopus
2-s2.0-84934300477