Increasing venoarterial extracorporeal membrane oxygenation flow negatively affects left ventricular performance in a porcine model of cardiogenic shock

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10297280" target="_blank" >RIV/00216208:11110/15:10297280 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21460/15:00237901

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s12967-015-0634-6" target="_blank" >http://dx.doi.org/10.1186/s12967-015-0634-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12967-015-0634-6" target="_blank" >10.1186/s12967-015-0634-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increasing venoarterial extracorporeal membrane oxygenation flow negatively affects left ventricular performance in a porcine model of cardiogenic shock

Popis výsledku v původním jazyce

Background: The aim of this study was to assess the relationship between extracorporeal blood flow (EBF) and left ventricular (LV) performance during venoarterial extracorporeal membrane oxygenation (VA ECMO) therapy. Methods: Five swine (body weight 45kg) underwent VA ECMO implantation under general anesthesia and artificial ventilation. Subsequently, acute cardiogenic shock with signs of tissue hypoxia was induced. Hemodynamic and cardiac performance parameters were then measured at different levelsof EBF (ranging from 1 to 5 L/min) using arterial and venous catheters, a pulmonary artery catheter and a pressure-volume loop catheter introduced into the left ventricle. Results: Myocardial hypoxia resulted in a decline in mean (+/- SEM) cardiac outputto 2.8 +/- 0.3 L/min and systolic blood pressure (SBP) to 60 +/- 7 mmHg. With an increase in EBF from 1 to 5 L/min, SBP increased to 97 +/- 8 mmHg (P < 0.001); however, increasing EBF from 1 to 5 L/min significantly negatively influences

Název v anglickém jazyce

Increasing venoarterial extracorporeal membrane oxygenation flow negatively affects left ventricular performance in a porcine model of cardiogenic shock

Popis výsledku anglicky

Background: The aim of this study was to assess the relationship between extracorporeal blood flow (EBF) and left ventricular (LV) performance during venoarterial extracorporeal membrane oxygenation (VA ECMO) therapy. Methods: Five swine (body weight 45kg) underwent VA ECMO implantation under general anesthesia and artificial ventilation. Subsequently, acute cardiogenic shock with signs of tissue hypoxia was induced. Hemodynamic and cardiac performance parameters were then measured at different levelsof EBF (ranging from 1 to 5 L/min) using arterial and venous catheters, a pulmonary artery catheter and a pressure-volume loop catheter introduced into the left ventricle. Results: Myocardial hypoxia resulted in a decline in mean (+/- SEM) cardiac outputto 2.8 +/- 0.3 L/min and systolic blood pressure (SBP) to 60 +/- 7 mmHg. With an increase in EBF from 1 to 5 L/min, SBP increased to 97 +/- 8 mmHg (P < 0.001); however, increasing EBF from 1 to 5 L/min significantly negatively influences

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Translational Medicine

ISSN

1479-5876

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

August

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

—

Kód UT WoS článku

000359451700001

EID výsledku v databázi Scopus

2-s2.0-84939148757