Hyaluronic acid as a modulator of the cytotoxic effects of cationic surfactants

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10306885" target="_blank" >RIV/00216208:11110/15:10306885 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/15:10306885 RIV/00216208:11140/15:10306885 RIV/00216305:26310/15:PU115196

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.colsurfa.2015.06.058" target="_blank" >http://dx.doi.org/10.1016/j.colsurfa.2015.06.058</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.colsurfa.2015.06.058" target="_blank" >10.1016/j.colsurfa.2015.06.058</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hyaluronic acid as a modulator of the cytotoxic effects of cationic surfactants

Popis výsledku v původním jazyce

CTAB (cetyltrimethylammonium bromide) and Septonex (carbethoxypendecinium bromide) are cationic surfactants known for harmful effects on different cell types (bacteria, fungi, mammal cells, etc.). Colloidal complexes of CTAB or Septonex with oppositely charged hyaluronic acid (HyA), based primarily on electrostatic interactions, were prepared with the aim to test potential modulation of surfactants cytotoxic effects. Complexes were tested for their cytotoxicity on human osteoblasts the cell metabolic activity was determined after 24h of treatment. Our data show that CTAB-HyA or Septonex-HyA complexes reduce (in different rate according to the used surfactant and HyA concentrations) cytotoxicity of both surfactants in all tested concentrations. In addition, a significant role of fetal bovine serum (important supplement of cell culture medium) in cell recovery under the stress conditions like CTAB or Septonex presence was observed. Taken together, HyA could be a useful modulator of CTAB

Název v anglickém jazyce

Hyaluronic acid as a modulator of the cytotoxic effects of cationic surfactants

Popis výsledku anglicky

CTAB (cetyltrimethylammonium bromide) and Septonex (carbethoxypendecinium bromide) are cationic surfactants known for harmful effects on different cell types (bacteria, fungi, mammal cells, etc.). Colloidal complexes of CTAB or Septonex with oppositely charged hyaluronic acid (HyA), based primarily on electrostatic interactions, were prepared with the aim to test potential modulation of surfactants cytotoxic effects. Complexes were tested for their cytotoxicity on human osteoblasts the cell metabolic activity was determined after 24h of treatment. Our data show that CTAB-HyA or Septonex-HyA complexes reduce (in different rate according to the used surfactant and HyA concentrations) cytotoxicity of both surfactants in all tested concentrations. In addition, a significant role of fetal bovine serum (important supplement of cell culture medium) in cell recovery under the stress conditions like CTAB or Septonex presence was observed. Taken together, HyA could be a useful modulator of CTAB

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Colloids and Surfaces A: Physicochemical and Engineering Aspects

ISSN

0927-7757

e-ISSN

—

Svazek periodika

483

Číslo periodika v rámci svazku

October

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

155-161

Kód UT WoS článku

000362146200021

EID výsledku v databázi Scopus

2-s2.0-84941745599