Buccal epithelial cells as potential non-invasive materials for the monitoring of mitochondrial disturbances to track Huntington's disease progression : a pilot study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10315942" target="_blank" >RIV/00216208:11110/15:10315942 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985904:_____/15:00452792 RIV/00064165:_____/15:10315942

Výsledek na webu

<a href="http://dx.doi.org/10.14735/amcsnn2012S49" target="_blank" >http://dx.doi.org/10.14735/amcsnn2012S49</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn2012S49" target="_blank" >10.14735/amcsnn2012S49</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Buccal epithelial cells as potential non-invasive materials for the monitoring of mitochondrial disturbances to track Huntington's disease progression : a pilot study

Popis výsledku v původním jazyce

Introduction: Huntington's disease (HD) is an incurable neurodegenerative disorder that manifests progressive behavioral and motoric changes and cognitive dysfunction. It is caused by CAG expansion in huntingtin gene and has almost full penetrance. The striatum is the most affected tissue in HD, but pathological changes are also detected in the peripheral tissues like blood, skeletal muscle or fibroblasts. Intensive HD research in the last years has revealed an important role of mitochondrial dysfunction in the pathogenesis and progression of the disease, which includes changes in the activity of the respiratory chain complexes, ATP synthesis or increased apoptotic stimuli. Aim and material: We decided to analyse the amount of mitochondrial respiratorychain complex I and IV in the epithelial cells of buccal smear in six HD patients and from an animal disease model, minipigs transgenic for the N-terminal part of human mutated huntingtin (TgHD). Methods: The amount of mitochondrial comp

Název v anglickém jazyce

Buccal epithelial cells as potential non-invasive materials for the monitoring of mitochondrial disturbances to track Huntington's disease progression : a pilot study

Popis výsledku anglicky

Introduction: Huntington's disease (HD) is an incurable neurodegenerative disorder that manifests progressive behavioral and motoric changes and cognitive dysfunction. It is caused by CAG expansion in huntingtin gene and has almost full penetrance. The striatum is the most affected tissue in HD, but pathological changes are also detected in the peripheral tissues like blood, skeletal muscle or fibroblasts. Intensive HD research in the last years has revealed an important role of mitochondrial dysfunction in the pathogenesis and progression of the disease, which includes changes in the activity of the respiratory chain complexes, ATP synthesis or increased apoptotic stimuli. Aim and material: We decided to analyse the amount of mitochondrial respiratorychain complex I and IV in the epithelial cells of buccal smear in six HD patients and from an animal disease model, minipigs transgenic for the N-terminal part of human mutated huntingtin (TgHD). Methods: The amount of mitochondrial comp

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

—

Svazek periodika

78

Číslo periodika v rámci svazku

Suppl. 2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

"2S49"-"2S54"

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—