Mitochondrial/Oxidative Stress Biomarkers in Huntington’s Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F23%3A00577188" target="_blank" >RIV/67985904:_____/23:00577188 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-3-031-32815-2_13" target="_blank" >http://dx.doi.org/10.1007/978-3-031-32815-2_13</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-031-32815-2_13" target="_blank" >10.1007/978-3-031-32815-2_13</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mitochondrial/Oxidative Stress Biomarkers in Huntington’s Disease

Popis výsledku v původním jazyce

Huntington’s disease (HD) is a hereditary neurodegeneration caused by a mutation in the HTT gene, leading to mutated huntingtin protein aggregation. This results in a widespread dysregulation of cellular pathways and death of medium spiny neurons of the striatum. Due to the high metabolic demand of brain tissue, mitochondrial dysfunction and resulting oxidative stress are common pathological features contributing to many neurodegenerative diseases, including HD. In this review, we summarize studies that measured fluid biomarkers of oxidative stress in HD patients. At the current state of knowledge, none of the reviewed biomarkers can be used as a reliable measure of HD progression or response to treatment in isolation. However, combining biomarkers covering different aspects of mitochondrial dysfunction and oxidative stress with HD specific biomarkers could be a more promising strategy.

Název v anglickém jazyce

Mitochondrial/Oxidative Stress Biomarkers in Huntington’s Disease

Popis výsledku anglicky

Huntington’s disease (HD) is a hereditary neurodegeneration caused by a mutation in the HTT gene, leading to mutated huntingtin protein aggregation. This results in a widespread dysregulation of cellular pathways and death of medium spiny neurons of the striatum. Due to the high metabolic demand of brain tissue, mitochondrial dysfunction and resulting oxidative stress are common pathological features contributing to many neurodegenerative diseases, including HD. In this review, we summarize studies that measured fluid biomarkers of oxidative stress in HD patients. At the current state of knowledge, none of the reviewed biomarkers can be used as a reliable measure of HD progression or response to treatment in isolation. However, combining biomarkers covering different aspects of mitochondrial dysfunction and oxidative stress with HD specific biomarkers could be a more promising strategy.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10601 - Cell biology

Projekt

<a href="/cs/project/GA22-24983S" target="_blank" >GA22-24983S: Autofágie v patogenezi Huntingtonovy nemoci</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Biomarkers for Huntington's Disease

ISBN

978-3-031-32814-5

Počet stran výsledku

30

Strana od-do

321-350

Počet stran knihy

475

Název nakladatele

Springer

Místo vydání

Cham

Kód UT WoS kapitoly

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