CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F24%3A10479910" target="_blank" >RIV/00216208:11110/24:10479910 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/24:10479910

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=esVRDRq47W" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=esVRDRq47W</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/antiox13020191" target="_blank" >10.3390/antiox13020191</a>

Jazyk výsledku

angličtina

Název v původním jazyce

CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease

Popis výsledku v původním jazyce

The progress in understanding the pathogenesis and treatment of Alzheimer&apos;s disease (AD) is based on the recognition of the primary causes of the disease, which can be deduced from the knowledge of risk factors and biomarkers measurable in the early stages of the disease. Insights into the risk factors and the time course of biomarker abnormalities point to a role for the connection of amyloid beta (A beta) pathology, tau pathology, mitochondrial dysfunction, and oxidative stress in the onset and development of AD. Coenzyme Q(10) (CoQ(10)) is a lipid antioxidant and electron transporter in the mitochondrial electron transport system. The availability and activity of CoQ(10) is crucial for proper mitochondrial function and cellular bioenergetics. Based on the mitochondrial hypothesis of AD and the hypothesis of oxidative stress, the regulation of the efficiency of the oxidative phosphorylation system by means of CoQ(10) can be considered promising in restoring the mitochondrial function impaired in AD, or in preventing the onset of mitochondrial dysfunction and the development of amyloid and tau pathology in AD. This review summarizes the knowledge on the pathophysiology of AD, in which CoQ(10) may play a significant role, with the aim of evaluating the perspective of the pharmacotherapy of AD with CoQ(10) and its analogues.

Název v anglickém jazyce

CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease

Popis výsledku anglicky

The progress in understanding the pathogenesis and treatment of Alzheimer&apos;s disease (AD) is based on the recognition of the primary causes of the disease, which can be deduced from the knowledge of risk factors and biomarkers measurable in the early stages of the disease. Insights into the risk factors and the time course of biomarker abnormalities point to a role for the connection of amyloid beta (A beta) pathology, tau pathology, mitochondrial dysfunction, and oxidative stress in the onset and development of AD. Coenzyme Q(10) (CoQ(10)) is a lipid antioxidant and electron transporter in the mitochondrial electron transport system. The availability and activity of CoQ(10) is crucial for proper mitochondrial function and cellular bioenergetics. Based on the mitochondrial hypothesis of AD and the hypothesis of oxidative stress, the regulation of the efficiency of the oxidative phosphorylation system by means of CoQ(10) can be considered promising in restoring the mitochondrial function impaired in AD, or in preventing the onset of mitochondrial dysfunction and the development of amyloid and tau pathology in AD. This review summarizes the knowledge on the pathophysiology of AD, in which CoQ(10) may play a significant role, with the aim of evaluating the perspective of the pharmacotherapy of AD with CoQ(10) and its analogues.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NU23-04-00032" target="_blank" >NU23-04-00032: Mitochondriální toxicita oligomerů tau proteinu a její regulace léky na Alzheimerovu chorobu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Antioxidants

ISSN

2076-3921

e-ISSN

2076-3921

Svazek periodika

13

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

21

Strana od-do

191

Kód UT WoS článku

001175122800001

EID výsledku v databázi Scopus

2-s2.0-85187290279