Risk Factors in Ovarian Cancer: A Brief Overview

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F15%3A10320331" target="_blank" >RIV/00216208:11110/15:10320331 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Risk Factors in Ovarian Cancer: A Brief Overview

Popis výsledku v původním jazyce

The exact causes of the sporadic cases of the most malignant gynecological cancer, ovarian carcinoma, are still difficult to ascertain. However, they account for the vast majority of ovarian cancer cases (~ 85%). The remaining cases may be attributed togenetic alterations in genome, chromosomes, genes and regulatory factors. Within this group, germline mutations in BRCA1/2 and DNA mismatch repair genes are the best known genetic risk factors. The aim of the epidemiological studies is to find out the risk or protective factors, associated with the ovarian cancer. In this review, we focus on a brief survey of these factors, with emphasis put particularly on the genetic alterations, reproductive factors and life style factors along with dietary factors.Unfortunately, there is no factor found to be fully protective. On the other hand, there is also no factor known to result in 100% risk of development of ovarian cancer. Further investigations of factors associated with ovarian cancer are

Název v anglickém jazyce

Risk Factors in Ovarian Cancer: A Brief Overview

Popis výsledku anglicky

The exact causes of the sporadic cases of the most malignant gynecological cancer, ovarian carcinoma, are still difficult to ascertain. However, they account for the vast majority of ovarian cancer cases (~ 85%). The remaining cases may be attributed togenetic alterations in genome, chromosomes, genes and regulatory factors. Within this group, germline mutations in BRCA1/2 and DNA mismatch repair genes are the best known genetic risk factors. The aim of the epidemiological studies is to find out the risk or protective factors, associated with the ovarian cancer. In this review, we focus on a brief survey of these factors, with emphasis put particularly on the genetic alterations, reproductive factors and life style factors along with dietary factors.Unfortunately, there is no factor found to be fully protective. On the other hand, there is also no factor known to result in 100% risk of development of ovarian cancer. Further investigations of factors associated with ovarian cancer are

Druh

C - Kapitola v odborné knize

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Handbook on Ovarian Cancer: Risk Factors, Therapies and Prognosis

ISBN

978-1-63483-925-9

Počet stran výsledku

15

Strana od-do

1-15

Počet stran knihy

247

Název nakladatele

Nova Science Publishers

Místo vydání

New York

Kód UT WoS kapitoly

—