The Synthesis and Characterization of the Poly[N-vinylpyrrolidone-co-ethylidene-bis-3-(N-vinyl-2-pyrrolidone)] Hydrogel Matrix for Drug Delivery to the Gastrointestinal Tract

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F16%3A10328010" target="_blank" >RIV/00216208:11110/16:10328010 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/masy.201650042/epdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/masy.201650042/epdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/masy.201650042" target="_blank" >10.1002/masy.201650042</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The Synthesis and Characterization of the Poly[N-vinylpyrrolidone-co-ethylidene-bis-3-(N-vinyl-2-pyrrolidone)] Hydrogel Matrix for Drug Delivery to the Gastrointestinal Tract

Popis výsledku v původním jazyce

Hydrogels based on copolymers of N-vinylpyrrolidone and ethylidene-bis-3-(N-vinyl-2-pyrrolidone) (EBVP) were prepared as polymer matrices for controlled release of high loads of hydrophilic compounds into the gastrointestinal tract. EBVP was synthesized and used as a crosslinking agent for the N-vinylpyrrolidone monomer. The polymerization mixtures, containing 65-80 wt.% of the model pharmacologically active compound, were polymerized to create cylindrical formulations. The release experiments were carried out under conditions corresponding to the digestive tract. Various compositions of hydrogel matrices were tested to reveal the influence of the active compound content and the crosslinking ratio on the release kinetics. Processes such as hydrogel swelling, dissolution and formulation disintegration were evaluated. The results obtained show that the system offers many possibilities to control the drug release to meet various medicinal requirements.

Název v anglickém jazyce

The Synthesis and Characterization of the Poly[N-vinylpyrrolidone-co-ethylidene-bis-3-(N-vinyl-2-pyrrolidone)] Hydrogel Matrix for Drug Delivery to the Gastrointestinal Tract

Popis výsledku anglicky

Hydrogels based on copolymers of N-vinylpyrrolidone and ethylidene-bis-3-(N-vinyl-2-pyrrolidone) (EBVP) were prepared as polymer matrices for controlled release of high loads of hydrophilic compounds into the gastrointestinal tract. EBVP was synthesized and used as a crosslinking agent for the N-vinylpyrrolidone monomer. The polymerization mixtures, containing 65-80 wt.% of the model pharmacologically active compound, were polymerized to create cylindrical formulations. The release experiments were carried out under conditions corresponding to the digestive tract. Various compositions of hydrogel matrices were tested to reveal the influence of the active compound content and the crosslinking ratio on the release kinetics. Processes such as hydrogel swelling, dissolution and formulation disintegration were evaluated. The results obtained show that the system offers many possibilities to control the drug release to meet various medicinal requirements.

Druh

D - Stať ve sborníku

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Macromolecular Symposia

ISBN

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ISSN

1022-1360

e-ISSN

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Počet stran výsledku

9

Strana od-do

14-22

Název nakladatele

Wiley - V C H Verlag GmbH &amp; Co. KGaA

Místo vydání

Weinheim

Místo konání akce

Nepal Polymer Inst, Kathmandu

Datum konání akce

7. 9. 2014

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000383600000003