The synthesis and characterization of the poly[N-vinylpyrrolidone-co-ethylidene-bis-3-(N-vinyl-2-pyrrolidone)] hydrogel matrix for drug delivery to the gastrointestinal tract
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F16%3A00462064" target="_blank" >RIV/61389013:_____/16:00462064 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1002/masy.201650042" target="_blank" >http://dx.doi.org/10.1002/masy.201650042</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/masy.201650042" target="_blank" >10.1002/masy.201650042</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The synthesis and characterization of the poly[N-vinylpyrrolidone-co-ethylidene-bis-3-(N-vinyl-2-pyrrolidone)] hydrogel matrix for drug delivery to the gastrointestinal tract
Popis výsledku v původním jazyce
Hydrogels based on copolymers of N-vinylpyrrolidone and ethylidene-bis-3-(N-vinyl-2-pyrrolidone) (EBVP) were prepared as polymer matrices for controlled release of high loads of hydrophilic compounds into the gastrointestinal tract. EBVP was synthesized and used as a crosslinking agent for the N-vinylpyrrolidone monomer. The polymerization mixtures, containing 65–80 wt.% of the model pharmacologically active compound, were polymerized to create cylindrical formulations. The release experiments were carried out under conditions corresponding to the digestive tract. Various compositions of hydrogel matrices were tested to reveal the influence of the active compound content and the crosslinking ratio on the release kinetics. Processes such as hydrogel swelling, dissolution and formulation disintegration were evaluated. The results obtained show that the system offers many possibilities to control the drug release to meet various medicinal requirements.
Název v anglickém jazyce
The synthesis and characterization of the poly[N-vinylpyrrolidone-co-ethylidene-bis-3-(N-vinyl-2-pyrrolidone)] hydrogel matrix for drug delivery to the gastrointestinal tract
Popis výsledku anglicky
Hydrogels based on copolymers of N-vinylpyrrolidone and ethylidene-bis-3-(N-vinyl-2-pyrrolidone) (EBVP) were prepared as polymer matrices for controlled release of high loads of hydrophilic compounds into the gastrointestinal tract. EBVP was synthesized and used as a crosslinking agent for the N-vinylpyrrolidone monomer. The polymerization mixtures, containing 65–80 wt.% of the model pharmacologically active compound, were polymerized to create cylindrical formulations. The release experiments were carried out under conditions corresponding to the digestive tract. Various compositions of hydrogel matrices were tested to reveal the influence of the active compound content and the crosslinking ratio on the release kinetics. Processes such as hydrogel swelling, dissolution and formulation disintegration were evaluated. The results obtained show that the system offers many possibilities to control the drug release to meet various medicinal requirements.
Klasifikace
Druh
D - Stať ve sborníku
CEP obor
CD - Makromolekulární chemie
OECD FORD obor
—
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název statě ve sborníku
Macromolecular Symposia. Volume 366, Issue 1
ISBN
—
ISSN
1521-3900
e-ISSN
—
Počet stran výsledku
9
Strana od-do
14-22
Název nakladatele
Wiley - V C H Verlag GmbH & Co. KGaA
Místo vydání
Weinheim
Místo konání akce
Kathmandu
Datum konání akce
7. 9. 2014
Typ akce podle státní příslušnosti
WRD - Celosvětová akce
Kód UT WoS článku
000383600000003