Clinical and laboratory predictors of Infectious Complications in patients after Out-of-Hospital Cardiac Arrest

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10360915" target="_blank" >RIV/00216208:11110/17:10360915 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/17:43913436 RIV/00064173:_____/17:N0000139

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jcrc.2017.07.010" target="_blank" >http://dx.doi.org/10.1016/j.jcrc.2017.07.010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jcrc.2017.07.010" target="_blank" >10.1016/j.jcrc.2017.07.010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical and laboratory predictors of Infectious Complications in patients after Out-of-Hospital Cardiac Arrest

Popis výsledku v původním jazyce

PURPOSE: Identification of clinical and laboratory predictors related to Infectious Complications (ICs) in patients after Out-of-Hospital Cardiac Arrest (OHCA). METHODS: Patients, aged &gt;18, after an OHCA between 9/2013 and 11/2015, surviving &gt;24h, were studied. RESULTS: Study group consisted of 42 patients (mean age 63.4years, 88.1% men). Forty percent of patients had IC; lower respiratory tract infections were most common (87.5% of cases). ICs were more common in patients receiving Targeted Temperature Management (50% vs. 10%; p=0.032). Antibiotics were used in 85.7% of patients. The mean time to therapy initiation was 9.6 (SD 7.1) hours after admission. The mean course of treatment was 9.0 (SD 6.2) days. Fifty-three percent of patients receiving early antibiotic treatment didn&apos;t have IC. Initial antibiotic therapy was changed more often in patients with IC (75% vs. 38.9%; p=0.045). C-Reactive Protein, Procalcitonin, Troponin and White Blood Cell count values were higher in patients with IC. CONCLUSION: Early initiated antibiotic treatment is overused in patients after OHCA. This practice is associated with necessitating antibiotic change in the majority of patients with IC. Assessment of clinical and laboratory parameters in the first days after OHCA increases the likelihood of appropriate ATB therapy.

Název v anglickém jazyce

Clinical and laboratory predictors of Infectious Complications in patients after Out-of-Hospital Cardiac Arrest

Popis výsledku anglicky

PURPOSE: Identification of clinical and laboratory predictors related to Infectious Complications (ICs) in patients after Out-of-Hospital Cardiac Arrest (OHCA). METHODS: Patients, aged &gt;18, after an OHCA between 9/2013 and 11/2015, surviving &gt;24h, were studied. RESULTS: Study group consisted of 42 patients (mean age 63.4years, 88.1% men). Forty percent of patients had IC; lower respiratory tract infections were most common (87.5% of cases). ICs were more common in patients receiving Targeted Temperature Management (50% vs. 10%; p=0.032). Antibiotics were used in 85.7% of patients. The mean time to therapy initiation was 9.6 (SD 7.1) hours after admission. The mean course of treatment was 9.0 (SD 6.2) days. Fifty-three percent of patients receiving early antibiotic treatment didn&apos;t have IC. Initial antibiotic therapy was changed more often in patients with IC (75% vs. 38.9%; p=0.045). C-Reactive Protein, Procalcitonin, Troponin and White Blood Cell count values were higher in patients with IC. CONCLUSION: Early initiated antibiotic treatment is overused in patients after OHCA. This practice is associated with necessitating antibiotic change in the majority of patients with IC. Assessment of clinical and laboratory parameters in the first days after OHCA increases the likelihood of appropriate ATB therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Critical Care

ISSN

0883-9441

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

85-91

Kód UT WoS článku

000418520500016

EID výsledku v databázi Scopus

2-s2.0-85030689029