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Combination of dual-phase and dual-tracer SPECT/CT imaging with voxel-based subtraction in the assessment of normocalcemic primary hyperparathyroidism in patients with osteoporosis: a pilot study

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10361051" target="_blank" >RIV/00216208:11110/17:10361051 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00064203:_____/17:10361051 RIV/00023728:_____/17:N0000024 RIV/00064165:_____/17:10361051

  • Výsledek na webu

    <a href="http://www.ijcem.com/files/ijcem0052090.pdf" target="_blank" >http://www.ijcem.com/files/ijcem0052090.pdf</a>

  • DOI - Digital Object Identifier

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Combination of dual-phase and dual-tracer SPECT/CT imaging with voxel-based subtraction in the assessment of normocalcemic primary hyperparathyroidism in patients with osteoporosis: a pilot study

  • Popis výsledku v původním jazyce

    Objective: We hypothesized that parathyroid (PT) scintigraphy could be clinically valid in identifying patients, indicated for parathyroidectomy, presenting with consistently elevated PTH and normal serum calcium concentrations. Methods: The parathyroid was examined using Tc-99m-MIBI and (TcO4)-Tc-99m SPECT imaging in 75 patients with a BMD &lt;= -2.5 T (lumbar spine, proximal femur, or distal one-third of the radius) with concomitantly elevated serum PTH concentration. Results: After excluding patients with secondary hyperparathyroidism, PT scintigraphy indicated the presence of an adenoma in all patients (32) with elevated serum PTH and calcium concentrations. After parathyroidectomy, PT adenoma was confirmed in all surgically treated patients (29). The predictive positive value of PT scintigraphy was 87%. PT scintigraphy indicated the presence of an adenoma in 26/34 patients with elevated serum PTH and normal calcium concentrations. Of these patients, 12 were indicated for parathyroidectomy; PT adenoma was found in all cases. In these patients, the predictive positive value was 85%. In 8 patients with increased PTH and normal serum calcium, scintigraphy did not reveal an enlarged PT. In these patients, serum PTH was significantly lower compared to patients with increased calcium and PTH. Conclusion: The combined dual-phase/dual-tracer SPECT imaging method, including low-dose CT, improves the identification of pathological parathyroid glands and is therefore suitable for presurgical detection of both typical primary hyperparathyroidism and normocalcemic primary hyperparathyroidism. The method should be of value for better management of the increasing number of cases seen in subspecialty metabolic bone practices.

  • Název v anglickém jazyce

    Combination of dual-phase and dual-tracer SPECT/CT imaging with voxel-based subtraction in the assessment of normocalcemic primary hyperparathyroidism in patients with osteoporosis: a pilot study

  • Popis výsledku anglicky

    Objective: We hypothesized that parathyroid (PT) scintigraphy could be clinically valid in identifying patients, indicated for parathyroidectomy, presenting with consistently elevated PTH and normal serum calcium concentrations. Methods: The parathyroid was examined using Tc-99m-MIBI and (TcO4)-Tc-99m SPECT imaging in 75 patients with a BMD &lt;= -2.5 T (lumbar spine, proximal femur, or distal one-third of the radius) with concomitantly elevated serum PTH concentration. Results: After excluding patients with secondary hyperparathyroidism, PT scintigraphy indicated the presence of an adenoma in all patients (32) with elevated serum PTH and calcium concentrations. After parathyroidectomy, PT adenoma was confirmed in all surgically treated patients (29). The predictive positive value of PT scintigraphy was 87%. PT scintigraphy indicated the presence of an adenoma in 26/34 patients with elevated serum PTH and normal calcium concentrations. Of these patients, 12 were indicated for parathyroidectomy; PT adenoma was found in all cases. In these patients, the predictive positive value was 85%. In 8 patients with increased PTH and normal serum calcium, scintigraphy did not reveal an enlarged PT. In these patients, serum PTH was significantly lower compared to patients with increased calcium and PTH. Conclusion: The combined dual-phase/dual-tracer SPECT imaging method, including low-dose CT, improves the identification of pathological parathyroid glands and is therefore suitable for presurgical detection of both typical primary hyperparathyroidism and normocalcemic primary hyperparathyroidism. The method should be of value for better management of the increasing number of cases seen in subspecialty metabolic bone practices.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30224 - Radiology, nuclear medicine and medical imaging

Návaznosti výsledku

  • Projekt

  • Návaznosti

    V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Ostatní

  • Rok uplatnění

    2017

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    International Journal of Clinical and Experimental Medicine

  • ISSN

    1940-5901

  • e-ISSN

  • Svazek periodika

    10

  • Číslo periodika v rámci svazku

    6

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    8

  • Strana od-do

    9518-9525

  • Kód UT WoS článku

    000404534900103

  • EID výsledku v databázi Scopus

    2-s2.0-85021366552