PETC/CT with 18F‑Choline localizes hyperfunctioning parathyroid adenomas equally well in normocalcemic hyperparathyroidism as in overt hyperparathyroidism.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73597860" target="_blank" >RIV/61989592:15110/19:73597860 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007%2Fs40618-018-0931-z" target="_blank" >https://link.springer.com/article/10.1007%2Fs40618-018-0931-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40618-018-0931-z" target="_blank" >10.1007/s40618-018-0931-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

PETC/CT with 18F‑Choline localizes hyperfunctioning parathyroid adenomas equally well in normocalcemic hyperparathyroidism as in overt hyperparathyroidism.

Popis výsledku v původním jazyce

Purpose: Identification of pathologic parathyroid glands in primary hyperparathyroidism, traditionally based on neck ultrasound (US) and/or 99m Tc-Sestamibi scintigraphy, can be challenging. PET/CT with 18 F-Fluorocholine ( 18 F-FCH) might improve the detection of pathologic parathyroid glands. We aimed at comparing the diagnostic performance of 18 F-FCH-PET/CT with that of dual-phase dual-isotope parathyroid scintigraphy and neck US. Methods: Thirty-four consecutive patients with primary hyperparathyroidism were prospectively enrolled, 7 had normocalcemic hyperparathyroidism, and 27 had classic hypercalcemic hyperparathyroidism. All patients underwent high-resolution neck US, dual-phase dual-isotope 99m Tc-Pertechnetate/ 99m Tc-Sestamibi scintigraphy, and 18 F-FCH-PET/CT. Results: In the whole patients’ group, the detection rates of the abnormal parathyroid gland were 68% for neck US, 71% for 18 F-FCH-PET/CT, and only 15% for 99m Tc-Sestamibi scintigraphy. The corresponding figures in normocalcemic and hypercalcemic hyperparathyroidism were 57 and 70% for neck US, 70 and 71% for 18 F-FCH-PET/CT, and 0 and 18% for 99m Tc-Sestamibi scintigraphy, respectively. In the 17 patients in whom the abnormal parathyroid gland was identified, either at surgery or at fine needle aspiration cytology/biochemistry, the correct detection rate was 82% for neck US, 89% for 18 F-FCH-PET/CT, and only 17% for 99m Tc-Sestamibi scintigraphy. Conclusions: 18 F-FCH-PET/CT can be considered a first-line imaging technique for the identification of pathologic parathyroid glands in patients with normocalcemic and hypercalcemic hyperparathyroidism, even when the parathyroid volume is small.

Název v anglickém jazyce

PETC/CT with 18F‑Choline localizes hyperfunctioning parathyroid adenomas equally well in normocalcemic hyperparathyroidism as in overt hyperparathyroidism.

Popis výsledku anglicky

Purpose: Identification of pathologic parathyroid glands in primary hyperparathyroidism, traditionally based on neck ultrasound (US) and/or 99m Tc-Sestamibi scintigraphy, can be challenging. PET/CT with 18 F-Fluorocholine ( 18 F-FCH) might improve the detection of pathologic parathyroid glands. We aimed at comparing the diagnostic performance of 18 F-FCH-PET/CT with that of dual-phase dual-isotope parathyroid scintigraphy and neck US. Methods: Thirty-four consecutive patients with primary hyperparathyroidism were prospectively enrolled, 7 had normocalcemic hyperparathyroidism, and 27 had classic hypercalcemic hyperparathyroidism. All patients underwent high-resolution neck US, dual-phase dual-isotope 99m Tc-Pertechnetate/ 99m Tc-Sestamibi scintigraphy, and 18 F-FCH-PET/CT. Results: In the whole patients’ group, the detection rates of the abnormal parathyroid gland were 68% for neck US, 71% for 18 F-FCH-PET/CT, and only 15% for 99m Tc-Sestamibi scintigraphy. The corresponding figures in normocalcemic and hypercalcemic hyperparathyroidism were 57 and 70% for neck US, 70 and 71% for 18 F-FCH-PET/CT, and 0 and 18% for 99m Tc-Sestamibi scintigraphy, respectively. In the 17 patients in whom the abnormal parathyroid gland was identified, either at surgery or at fine needle aspiration cytology/biochemistry, the correct detection rate was 82% for neck US, 89% for 18 F-FCH-PET/CT, and only 17% for 99m Tc-Sestamibi scintigraphy. Conclusions: 18 F-FCH-PET/CT can be considered a first-line imaging technique for the identification of pathologic parathyroid glands in patients with normocalcemic and hypercalcemic hyperparathyroidism, even when the parathyroid volume is small.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Endocrinological Investigation

ISSN

0391-4097

e-ISSN

—

Svazek periodika

42

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

419-426

Kód UT WoS článku

000463248300007

EID výsledku v databázi Scopus

2-s2.0-85051301533