Toxocara spp. seronegativity in Czech patients with early form of multiple sclerosis - Clinically isolated syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10364600" target="_blank" >RIV/00216208:11110/17:10364600 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/17:10364600

Výsledek na webu

<a href="http://www.prolekare.cz/linkout/61744" target="_blank" >http://www.prolekare.cz/linkout/61744</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Toxocara spp. seronegativity in Czech patients with early form of multiple sclerosis - Clinically isolated syndrome

Popis výsledku v původním jazyce

Background: Helminth infections were reported to slightly modulate the host immune system response and decrease the risk of an autoimmune disorder, but on the other hand any infection may activate the immune system and trigger autoimmune reaction. In this study, we aimed to measure eosinophil levels and antibodies against Toxocara spp. in patients with clinically isolated syndrome (CIS) and multiple sclerosis (MS). Methods: In total, 220 CIS patients and 62 MS patients were examined. Antibodies against Toxocara secretory/excretory antigens (TES) were measured with an ELISA method. Results: A total of 1,983 measurements of eosinophil levels were performed in CIS patients, out of which 95 results in 21 different patients were above the upper normal limit of the laboratory, but it was mostly only a relative increase. Two patients showed eosinophil levels above 20 % but both of them suffered from severe allergy. None of the CIS patients had any clinical signs of parasitic infections and the serological tests for antibodies against Toxocara were all negative. In all MS patients, eosinophil levels were in normal range. Antibodies against TES were detected in only 1 out of 62 (1.6%) MS patients. Conclusions: Based on our results it does not seem that Toxocara infection represents a potential trigger of MS. Nevertheless, our study indirectly confirms the hypothesis that parasitic infection may protect from autoimmunity.

Název v anglickém jazyce

Toxocara spp. seronegativity in Czech patients with early form of multiple sclerosis - Clinically isolated syndrome

Popis výsledku anglicky

Background: Helminth infections were reported to slightly modulate the host immune system response and decrease the risk of an autoimmune disorder, but on the other hand any infection may activate the immune system and trigger autoimmune reaction. In this study, we aimed to measure eosinophil levels and antibodies against Toxocara spp. in patients with clinically isolated syndrome (CIS) and multiple sclerosis (MS). Methods: In total, 220 CIS patients and 62 MS patients were examined. Antibodies against Toxocara secretory/excretory antigens (TES) were measured with an ELISA method. Results: A total of 1,983 measurements of eosinophil levels were performed in CIS patients, out of which 95 results in 21 different patients were above the upper normal limit of the laboratory, but it was mostly only a relative increase. Two patients showed eosinophil levels above 20 % but both of them suffered from severe allergy. None of the CIS patients had any clinical signs of parasitic infections and the serological tests for antibodies against Toxocara were all negative. In all MS patients, eosinophil levels were in normal range. Antibodies against TES were detected in only 1 out of 62 (1.6%) MS patients. Conclusions: Based on our results it does not seem that Toxocara infection represents a potential trigger of MS. Nevertheless, our study indirectly confirms the hypothesis that parasitic infection may protect from autoimmunity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Epidemiologie, mikrobiologie, imunologie

ISSN

1210-7913

e-ISSN

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Svazek periodika

66

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

124-127

Kód UT WoS článku

000411767000003

EID výsledku v databázi Scopus

2-s2.0-85030231732