The development and origins of vertebrate meninges

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F17%3A10366841" target="_blank" >RIV/00216208:11110/17:10366841 - isvavai.cz</a>

Výsledek na webu

<a href="https://biocomm.spbu.ru/article/view/10/75" target="_blank" >https://biocomm.spbu.ru/article/view/10/75</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21638/11701/spbu03.2017.203" target="_blank" >10.21638/11701/spbu03.2017.203</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The development and origins of vertebrate meninges

Popis výsledku v původním jazyce

Meninges comprise three distinct layers, the dura mater, arachnoid, and pia mater that surround the brain, spinal cord and some parts of the nerves. Tradi- tionally the meninges were believed to serve only as protection for tissues that they encase. However recent work shows they have other important functions related to development and regulation of the nervous system. Given the impor- tance of the meninges, it is surprising that we know very little about their devel- opment. The embryological origin of the meninges has been debated for over a hundred years. Some studies imply that the meninges develop from the neural crest, while others suggest that they come from the somites. Here, we investi- gated the temporal development of meninges in birds and mice and found they form at comparable stages. We investigated the origin of avian spinal meninges using chick/quail cell tracing protocols and found they do not develop from the somites as previously thought. We propose that meningeal epithelial blood vessels may have been mistaken as meninges and led to an erroneous conclu- sion by previous investigators. We present data that show that avian spinal me- ninges originated from the neural crest supported by data demonstrating that they express the neural crest marker HNK1. Finally using the Wnt1-Cre mouse we show that trunk meninges of mammals also originate from neural crest.

Název v anglickém jazyce

The development and origins of vertebrate meninges

Popis výsledku anglicky

Meninges comprise three distinct layers, the dura mater, arachnoid, and pia mater that surround the brain, spinal cord and some parts of the nerves. Tradi- tionally the meninges were believed to serve only as protection for tissues that they encase. However recent work shows they have other important functions related to development and regulation of the nervous system. Given the impor- tance of the meninges, it is surprising that we know very little about their devel- opment. The embryological origin of the meninges has been debated for over a hundred years. Some studies imply that the meninges develop from the neural crest, while others suggest that they come from the somites. Here, we investi- gated the temporal development of meninges in birds and mice and found they form at comparable stages. We investigated the origin of avian spinal meninges using chick/quail cell tracing protocols and found they do not develop from the somites as previously thought. We propose that meningeal epithelial blood vessels may have been mistaken as meninges and led to an erroneous conclu- sion by previous investigators. We present data that show that avian spinal me- ninges originated from the neural crest supported by data demonstrating that they express the neural crest marker HNK1. Finally using the Wnt1-Cre mouse we show that trunk meninges of mammals also originate from neural crest.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

10605 - Developmental biology

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biological Communications

ISSN

2542-2154

e-ISSN

—

Svazek periodika

62

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

RU - Ruská federace

Počet stran výsledku

9

Strana od-do

73-81

Kód UT WoS článku

—

EID výsledku v databázi Scopus

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