Pupillometry as an indicator of L-DOPA dosages in Parkinson's disease patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10374158" target="_blank" >RIV/00216208:11110/18:10374158 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/18:10374158

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00702-017-1829-1" target="_blank" >http://dx.doi.org/10.1007/s00702-017-1829-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-017-1829-1" target="_blank" >10.1007/s00702-017-1829-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pupillometry as an indicator of L-DOPA dosages in Parkinson's disease patients

Popis výsledku v původním jazyce

Dopamine was shown to induce mydriasis by excitation of alpha-adrenergic receptors at the dilator pupillae muscle. Pupilla diameter may thus serve as an indirect measure of peripheral pharmacokinetics of l-DOPA and dopamine. The aim of this study is to evaluate the effect of l-DOPA dosage on pupillometric parameters in Parkinson&apos;s disease (PD) patients. Sixteen PD patients and 14 healthy control subjects (CS) were studied. The statistical analysis revealed significant differences between CS and PD patients for the mean maximum and minimum pupil diameters (p = 0.017, p = 0.028, respectively), with higher values found in PD. Moreover, a significant dose-response relationship was found between the maximum pupil diameter and both the morning l-DOPA dose (R (2) = 0.78) and the total daily l-DOPA dose (R (2) = 0.93). A sigmoid-shaped curve best describes the dose-response relationship, with a ceiling effect at about 400 mg l-DOPA daily dose. In conclusion, measuring pupillometric parameters represents a sensitive tool for non-invasive evaluation of the peripheral effect of l-DOPA, especially with daily doses below 400 mg l-DOPA.

Název v anglickém jazyce

Pupillometry as an indicator of L-DOPA dosages in Parkinson's disease patients

Popis výsledku anglicky

Dopamine was shown to induce mydriasis by excitation of alpha-adrenergic receptors at the dilator pupillae muscle. Pupilla diameter may thus serve as an indirect measure of peripheral pharmacokinetics of l-DOPA and dopamine. The aim of this study is to evaluate the effect of l-DOPA dosage on pupillometric parameters in Parkinson&apos;s disease (PD) patients. Sixteen PD patients and 14 healthy control subjects (CS) were studied. The statistical analysis revealed significant differences between CS and PD patients for the mean maximum and minimum pupil diameters (p = 0.017, p = 0.028, respectively), with higher values found in PD. Moreover, a significant dose-response relationship was found between the maximum pupil diameter and both the morning l-DOPA dose (R (2) = 0.78) and the total daily l-DOPA dose (R (2) = 0.93). A sigmoid-shaped curve best describes the dose-response relationship, with a ceiling effect at about 400 mg l-DOPA daily dose. In conclusion, measuring pupillometric parameters represents a sensitive tool for non-invasive evaluation of the peripheral effect of l-DOPA, especially with daily doses below 400 mg l-DOPA.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

—

Svazek periodika

125

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

5

Strana od-do

699-703

Kód UT WoS článku

000427658500007

EID výsledku v databázi Scopus

2-s2.0-85038368842