Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10376124" target="_blank" >RIV/00216208:11110/18:10376124 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023761:_____/18:N0000004 RIV/00023001:_____/18:00076901 RIV/00064165:_____/18:10376124

Výsledek na webu

<a href="https://doi.org/10.1038/s41387-018-0032-2" target="_blank" >https://doi.org/10.1038/s41387-018-0032-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41387-018-0032-2" target="_blank" >10.1038/s41387-018-0032-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation

Popis výsledku v původním jazyce

Background: Angiopoietin-like proteins (ANGPTLs) 3 and 4 are circulating factors that participate in the regulation of lipid and glucose metabolism. Subjects and methods: We measured serum ANGPTL3 and 4 levels in 23 patients with obesity, 40 patients with obesity and type 2 diabetes mellitus (T2DM), 22 patients with anorexia nervosa (AN), 15 subjects undergoing 72-h fasting, and 12 patients with short bowel syndrome (SBS), and their changes after very-low-calorie diet (VLCD), bariatric surgery, partial realimentation, acute fasting, and parenteral nutrition in order to assess their possible role in metabolic regulations. Results: Serum ANGPTL4 levels were higher in obese subjects without/with T2DM (94.50 +- 9.51 and 134.19 +- 7.69 vs. 50.34 +- 4.22 ng/ml, p &lt; 0.001) and lower in subjects with AN relative to healthy control subjects (38.22 +- 4.48 vs. 65.80 +- 7.98 ng/ml, p = 0.002), while serum ANGPTL3 levels demonstrated inverse tendency. Nutritional status had no effect on ANGPTL3 and 4 mRNA expression in adipose tissue. Fasting decreased ANGPTL3 and increased ANGPTL4 levels, while VLCD reduced only ANGPTL3. Bariatric surgery and realimentation of AN or SBS patients had no effect on either ANGPTL. Multiple regression analysis identified BMI as an independent predictor of ANGPTL3; and BMI and HbA1c as independent predictors of ANGPTL4, respectively. Conclusions: Taken together, our data suggest that serum ANGPTL3 and 4 levels are influenced by nutritional status and fasting and could be involved in the metabolic disturbances present in obesity and AN.

Název v anglickém jazyce

Angiopoietin-like protein 3 and 4 in obesity, type 2 diabetes mellitus, and malnutrition: the effect of weight reduction and realimentation

Popis výsledku anglicky

Background: Angiopoietin-like proteins (ANGPTLs) 3 and 4 are circulating factors that participate in the regulation of lipid and glucose metabolism. Subjects and methods: We measured serum ANGPTL3 and 4 levels in 23 patients with obesity, 40 patients with obesity and type 2 diabetes mellitus (T2DM), 22 patients with anorexia nervosa (AN), 15 subjects undergoing 72-h fasting, and 12 patients with short bowel syndrome (SBS), and their changes after very-low-calorie diet (VLCD), bariatric surgery, partial realimentation, acute fasting, and parenteral nutrition in order to assess their possible role in metabolic regulations. Results: Serum ANGPTL4 levels were higher in obese subjects without/with T2DM (94.50 +- 9.51 and 134.19 +- 7.69 vs. 50.34 +- 4.22 ng/ml, p &lt; 0.001) and lower in subjects with AN relative to healthy control subjects (38.22 +- 4.48 vs. 65.80 +- 7.98 ng/ml, p = 0.002), while serum ANGPTL3 levels demonstrated inverse tendency. Nutritional status had no effect on ANGPTL3 and 4 mRNA expression in adipose tissue. Fasting decreased ANGPTL3 and increased ANGPTL4 levels, while VLCD reduced only ANGPTL3. Bariatric surgery and realimentation of AN or SBS patients had no effect on either ANGPTL. Multiple regression analysis identified BMI as an independent predictor of ANGPTL3; and BMI and HbA1c as independent predictors of ANGPTL4, respectively. Conclusions: Taken together, our data suggest that serum ANGPTL3 and 4 levels are influenced by nutritional status and fasting and could be involved in the metabolic disturbances present in obesity and AN.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NV15-27863A" target="_blank" >NV15-27863A: Úloha gastrointestinálních hormonů a endokrinní dysfunkce střeva v etiopatogenezi syndromu krátkého střeva</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrition &amp; Diabetes [online]

ISSN

2044-4052

e-ISSN

—

Svazek periodika

8

Číslo periodika v rámci svazku

April

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000431723000004

EID výsledku v databázi Scopus

2-s2.0-85046120737