An Alternatively Activated Macrophage Marker CD163 in Severely Obese Patients: the Influence of Very Low-Calorie Diet and Bariatric Surgery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F17%3A00000377" target="_blank" >RIV/61383082:_____/17:00000377 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/17:10364724 RIV/00023761:_____/17:N0000031 RIV/00023001:_____/17:00076180 RIV/00216208:11110/17:10364724 RIV/00064165:_____/17:10364724

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pubmed/28406702" target="_blank" >https://www.ncbi.nlm.nih.gov/pubmed/28406702</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

An Alternatively Activated Macrophage Marker CD163 in Severely Obese Patients: the Influence of Very Low-Calorie Diet and Bariatric Surgery

Popis výsledku v původním jazyce

CD163 is a marker of macrophages with anti-inflammatory properties and its soluble form (sCD163) is considered a prognostic predictor of several diseases including type 2 diabetes mellitus (T2DM). We explored sCD163 levels at baseline and after very low-calorie diet (VLCD) or bariatric surgery in 32 patients with obesity (20 undergoing VLCD and 12 bariatric surgery), 32 obese patients with T2DM (22 undergoing VLCD and 10 bariatric surgery), and 19 control subjects. We also assessed the changes of CD163 positive cells of monocyte-macrophage lineage in peripheral blood and subcutaneous adipose tissue (SAT) in subset of patients. Plasma sCD163 levels were increased in obese and T2DM subjects relative to control subjects (467.2 +/- 40.2 and 513.8 +/- 37.0 vs. 334.4 +/- 24.8 ng/ml, p=0.001) and decreased after both interventions. Obesity decreased percentage of CD163+ CD14+ monocytes in peripheral blood compared to controls (78.9 +/- 1.48 vs. 86.2 +/- 1.31 %, p=0.003) and bariatric surgery decreased CD163+ CD14+ HLA-DR+ macrophages in SAT (19.4 +/- 2.32 vs. 11.3 +/- 0.90 %, p=0.004). Our data suggest that increased basal sCD163 levels are related to obesity and its metabolic complications. On the contrary, sCD163 or CD163 positive cell changes do not precisely reflect metabolic improvements after weight loss.

Název v anglickém jazyce

An Alternatively Activated Macrophage Marker CD163 in Severely Obese Patients: the Influence of Very Low-Calorie Diet and Bariatric Surgery

Popis výsledku anglicky

CD163 is a marker of macrophages with anti-inflammatory properties and its soluble form (sCD163) is considered a prognostic predictor of several diseases including type 2 diabetes mellitus (T2DM). We explored sCD163 levels at baseline and after very low-calorie diet (VLCD) or bariatric surgery in 32 patients with obesity (20 undergoing VLCD and 12 bariatric surgery), 32 obese patients with T2DM (22 undergoing VLCD and 10 bariatric surgery), and 19 control subjects. We also assessed the changes of CD163 positive cells of monocyte-macrophage lineage in peripheral blood and subcutaneous adipose tissue (SAT) in subset of patients. Plasma sCD163 levels were increased in obese and T2DM subjects relative to control subjects (467.2 +/- 40.2 and 513.8 +/- 37.0 vs. 334.4 +/- 24.8 ng/ml, p=0.001) and decreased after both interventions. Obesity decreased percentage of CD163+ CD14+ monocytes in peripheral blood compared to controls (78.9 +/- 1.48 vs. 86.2 +/- 1.31 %, p=0.003) and bariatric surgery decreased CD163+ CD14+ HLA-DR+ macrophages in SAT (19.4 +/- 2.32 vs. 11.3 +/- 0.90 %, p=0.004). Our data suggest that increased basal sCD163 levels are related to obesity and its metabolic complications. On the contrary, sCD163 or CD163 positive cell changes do not precisely reflect metabolic improvements after weight loss.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30212 - Surgery

Projekt

<a href="/cs/project/NV15-26854A" target="_blank" >NV15-26854A: Význam epikardiální tukové tkáně u onemocnění srdce: nové mechanizmy působení a jejich terapeutické ovlivnění</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

66

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

12

Strana od-do

641-652

Kód UT WoS článku

000412736000010

EID výsledku v databázi Scopus

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