MicroRNA expression in SMARCB1/INI1-deficient sinonasal carcinoma: a clinicopathological and molecular genetic study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F18%3A10382292" target="_blank" >RIV/00216208:11110/18:10382292 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/18:10382292 RIV/61989592:15110/18:73590696 RIV/00179906:_____/18:10382292 RIV/00064165:_____/18:10382292

Výsledek na webu

<a href="https://doi.org/10.1007/s00428-018-2293-5" target="_blank" >https://doi.org/10.1007/s00428-018-2293-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00428-018-2293-5" target="_blank" >10.1007/s00428-018-2293-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MicroRNA expression in SMARCB1/INI1-deficient sinonasal carcinoma: a clinicopathological and molecular genetic study

Popis výsledku v původním jazyce

The aim of the study was to evaluate microRNA expression in SMARCB1/INI1-deficient sinonasal carcinomas by means of polymerase chain reaction. A total of 4/56 (7 %) cases of SMARCB1/INI1-deficient carcinomas were detected among 56 sinonasal carcinomas using immunohistochemical screening. The series comprised 3 males and 1 female, aged 27 - 76 years (median 64 years). All tumors arose in the nasal cavity. Three neoplasms were diagnosed in an advanced stage pT4. During the follow-up period (range 14 - 122 months (median 72 months)), three tumors recurred locally and two patients died due to the tumor. Microscopically, the tumors were composed of basaloid cells with variable component of rhabdoid cells with eosinophilic cytoplasm. All tumors showed upregulation of both miR-9 and miR-21 and downregulation of miR-145. In summary, we described four cases of SMARCB1/INI1-deficient sinonasal carcinoma with novel findings on microRNA expression, which might be important for new therapeutic strategies in the future.

Název v anglickém jazyce

MicroRNA expression in SMARCB1/INI1-deficient sinonasal carcinoma: a clinicopathological and molecular genetic study

Popis výsledku anglicky

The aim of the study was to evaluate microRNA expression in SMARCB1/INI1-deficient sinonasal carcinomas by means of polymerase chain reaction. A total of 4/56 (7 %) cases of SMARCB1/INI1-deficient carcinomas were detected among 56 sinonasal carcinomas using immunohistochemical screening. The series comprised 3 males and 1 female, aged 27 - 76 years (median 64 years). All tumors arose in the nasal cavity. Three neoplasms were diagnosed in an advanced stage pT4. During the follow-up period (range 14 - 122 months (median 72 months)), three tumors recurred locally and two patients died due to the tumor. Microscopically, the tumors were composed of basaloid cells with variable component of rhabdoid cells with eosinophilic cytoplasm. All tumors showed upregulation of both miR-9 and miR-21 and downregulation of miR-145. In summary, we described four cases of SMARCB1/INI1-deficient sinonasal carcinoma with novel findings on microRNA expression, which might be important for new therapeutic strategies in the future.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30109 - Pathology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Virchows Archiv

ISSN

0945-6317

e-ISSN

—

Svazek periodika

472

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

5

Strana od-do

871-875

Kód UT WoS článku

000433027400018

EID výsledku v databázi Scopus

2-s2.0-85040330733