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Glottal Source Analysis of Voice Deficits in Newly Diagnosed Drug-naive Patients with Parkinson's Disease: Correlation Between Acoustic Speech Characteristics and Non-Speech Motor Performance

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10409539" target="_blank" >RIV/00216208:11110/20:10409539 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/68407700:21230/20:00339337

  • Výsledek na webu

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=r9xc_Nd5Yg" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=r9xc_Nd5Yg</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bspc.2019.101818" target="_blank" >10.1016/j.bspc.2019.101818</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Glottal Source Analysis of Voice Deficits in Newly Diagnosed Drug-naive Patients with Parkinson's Disease: Correlation Between Acoustic Speech Characteristics and Non-Speech Motor Performance

  • Popis výsledku v původním jazyce

    As dysphonia is assumed to be the most prevalent feature of hypokinetic dysarthria in Parkinson&apos;s disease (PD), several acoustic approaches have been introduced for its assessment. However, the sensitivity of different acoustic measures to the occurrence of dysphonia in drug-naïve de-novo patients with PD has not yet been explored. The goal of this study is to examine the performance of glottal source parametrization and compare it with traditional perturbation and cepstral measures. Sustained phonations of 40 de-novo drug-naïve PD participants and 40 age- and sex-matched healthy controls were recorded. Each utterance was ranked by a set of glottal source parameters obtained by inverse adaptive filtering, the perturbation parameters, and cepstral peak prominence measures. Our results revealed the significant differences in the glottal source parameter Harmonic Richness Factor (HRF: p &lt; 0.01) and cepstral peak prominence parameter (p &lt; 0.05). The support vector machine classification between PD and healthy controls reached the area under the curve of 0.78. The analysis of relationships showed significant negative correlations between HRF and total Movement Disorders Society - Unified Parkinson&apos;s Disease Rating Scale III score (r=-0.35, p &lt; 0.05), as well as its rigidity (r=-0.43, p &lt; 0.01) and bradykinesia (r=-0.32, p &lt; 0.05) sub-scores. Glottal source assessment appears to be a superior method to assess PD-related dysphonia compared to the traditional perturbation and cepstral approaches. Our results highlight that dysphonia and limb bradykinesia and rigidity in PD are controlled by similar underlying brain processes.

  • Název v anglickém jazyce

    Glottal Source Analysis of Voice Deficits in Newly Diagnosed Drug-naive Patients with Parkinson's Disease: Correlation Between Acoustic Speech Characteristics and Non-Speech Motor Performance

  • Popis výsledku anglicky

    As dysphonia is assumed to be the most prevalent feature of hypokinetic dysarthria in Parkinson&apos;s disease (PD), several acoustic approaches have been introduced for its assessment. However, the sensitivity of different acoustic measures to the occurrence of dysphonia in drug-naïve de-novo patients with PD has not yet been explored. The goal of this study is to examine the performance of glottal source parametrization and compare it with traditional perturbation and cepstral measures. Sustained phonations of 40 de-novo drug-naïve PD participants and 40 age- and sex-matched healthy controls were recorded. Each utterance was ranked by a set of glottal source parameters obtained by inverse adaptive filtering, the perturbation parameters, and cepstral peak prominence measures. Our results revealed the significant differences in the glottal source parameter Harmonic Richness Factor (HRF: p &lt; 0.01) and cepstral peak prominence parameter (p &lt; 0.05). The support vector machine classification between PD and healthy controls reached the area under the curve of 0.78. The analysis of relationships showed significant negative correlations between HRF and total Movement Disorders Society - Unified Parkinson&apos;s Disease Rating Scale III score (r=-0.35, p &lt; 0.05), as well as its rigidity (r=-0.43, p &lt; 0.01) and bradykinesia (r=-0.32, p &lt; 0.05) sub-scores. Glottal source assessment appears to be a superior method to assess PD-related dysphonia compared to the traditional perturbation and cepstral approaches. Our results highlight that dysphonia and limb bradykinesia and rigidity in PD are controlled by similar underlying brain processes.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30103 - Neurosciences (including psychophysiology)

Návaznosti výsledku

  • Projekt

    Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Biomedical Signal Processing and Control

  • ISSN

    1746-8094

  • e-ISSN

  • Svazek periodika

    57

  • Číslo periodika v rámci svazku

    March

  • Stát vydavatele periodika

    GB - Spojené království Velké Británie a Severního Irska

  • Počet stran výsledku

    9

  • Strana od-do

    101818

  • Kód UT WoS článku

    000512481800069

  • EID výsledku v databázi Scopus

    2-s2.0-85076003726