Glottal Source Analysis of Voice Deficits in Newly Diagnosed Drug-naive Patients with Parkinson's Disease: Correlation Between Acoustic Speech Characteristics and Non-Speech Motor Performance
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10409539" target="_blank" >RIV/00216208:11110/20:10409539 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68407700:21230/20:00339337
Výsledek na webu
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=r9xc_Nd5Yg" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=r9xc_Nd5Yg</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bspc.2019.101818" target="_blank" >10.1016/j.bspc.2019.101818</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Glottal Source Analysis of Voice Deficits in Newly Diagnosed Drug-naive Patients with Parkinson's Disease: Correlation Between Acoustic Speech Characteristics and Non-Speech Motor Performance
Popis výsledku v původním jazyce
As dysphonia is assumed to be the most prevalent feature of hypokinetic dysarthria in Parkinson's disease (PD), several acoustic approaches have been introduced for its assessment. However, the sensitivity of different acoustic measures to the occurrence of dysphonia in drug-naïve de-novo patients with PD has not yet been explored. The goal of this study is to examine the performance of glottal source parametrization and compare it with traditional perturbation and cepstral measures. Sustained phonations of 40 de-novo drug-naïve PD participants and 40 age- and sex-matched healthy controls were recorded. Each utterance was ranked by a set of glottal source parameters obtained by inverse adaptive filtering, the perturbation parameters, and cepstral peak prominence measures. Our results revealed the significant differences in the glottal source parameter Harmonic Richness Factor (HRF: p < 0.01) and cepstral peak prominence parameter (p < 0.05). The support vector machine classification between PD and healthy controls reached the area under the curve of 0.78. The analysis of relationships showed significant negative correlations between HRF and total Movement Disorders Society - Unified Parkinson's Disease Rating Scale III score (r=-0.35, p < 0.05), as well as its rigidity (r=-0.43, p < 0.01) and bradykinesia (r=-0.32, p < 0.05) sub-scores. Glottal source assessment appears to be a superior method to assess PD-related dysphonia compared to the traditional perturbation and cepstral approaches. Our results highlight that dysphonia and limb bradykinesia and rigidity in PD are controlled by similar underlying brain processes.
Název v anglickém jazyce
Glottal Source Analysis of Voice Deficits in Newly Diagnosed Drug-naive Patients with Parkinson's Disease: Correlation Between Acoustic Speech Characteristics and Non-Speech Motor Performance
Popis výsledku anglicky
As dysphonia is assumed to be the most prevalent feature of hypokinetic dysarthria in Parkinson's disease (PD), several acoustic approaches have been introduced for its assessment. However, the sensitivity of different acoustic measures to the occurrence of dysphonia in drug-naïve de-novo patients with PD has not yet been explored. The goal of this study is to examine the performance of glottal source parametrization and compare it with traditional perturbation and cepstral measures. Sustained phonations of 40 de-novo drug-naïve PD participants and 40 age- and sex-matched healthy controls were recorded. Each utterance was ranked by a set of glottal source parameters obtained by inverse adaptive filtering, the perturbation parameters, and cepstral peak prominence measures. Our results revealed the significant differences in the glottal source parameter Harmonic Richness Factor (HRF: p < 0.01) and cepstral peak prominence parameter (p < 0.05). The support vector machine classification between PD and healthy controls reached the area under the curve of 0.78. The analysis of relationships showed significant negative correlations between HRF and total Movement Disorders Society - Unified Parkinson's Disease Rating Scale III score (r=-0.35, p < 0.05), as well as its rigidity (r=-0.43, p < 0.01) and bradykinesia (r=-0.32, p < 0.05) sub-scores. Glottal source assessment appears to be a superior method to assess PD-related dysphonia compared to the traditional perturbation and cepstral approaches. Our results highlight that dysphonia and limb bradykinesia and rigidity in PD are controlled by similar underlying brain processes.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30103 - Neurosciences (including psychophysiology)
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Biomedical Signal Processing and Control
ISSN
1746-8094
e-ISSN
—
Svazek periodika
57
Číslo periodika v rámci svazku
March
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
9
Strana od-do
101818
Kód UT WoS článku
000512481800069
EID výsledku v databázi Scopus
2-s2.0-85076003726