Osmium absorption after osmium tetroxide skin and eye exposure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F20%3A10412652" target="_blank" >RIV/00216208:11110/20:10412652 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/20:43920207 RIV/00064190:_____/20:N0000057 RIV/00064165:_____/20:10412652 RIV/71009396:_____/20:N0000004

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=R1MP0zQQFh" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=R1MP0zQQFh</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/bcpt.13450" target="_blank" >10.1111/bcpt.13450</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Osmium absorption after osmium tetroxide skin and eye exposure

Popis výsledku v původním jazyce

Osmium tetroxide is a strong oxidizing agent used in electron microscopy. Eye exposure may cause severe burns, and after inhalation or ingestion damage to the respiratory or gastrointestinal tract occurs. Exposure to osmium and its compounds is extremely rare. We present a case of a 32-year-old female stained by 9 mL of 2% osmium tetroxide in acetone during an accident in the laboratory, with rare dermal and ocular findings. Due to lack of data in toxicological databases and the absence of antidote, the therapy was symptomatic. Osmium was detected in serum 19 hours later (0.22 mu g/L) and in urine during the 15-hour collection (three samples-7.05, 1.65 and 8.45 mu g/L). In blood serum on admission, after 1 and 2 days after exposure, the levels of iron (28.2, 39.8 and 50.5 mu mol/L; reference range 5.8-34.5 mu mol/L) and transferrin receptor/ferritine were elevated. To our knowledge, this is the first paper documenting a significant absorption from the skin and potentially from the eye conjunctiva, based on serum and urine analysis. The relationship between increased iron in blood and exposure has not been described yet, and the mechanism remains unknown. The patient is being followed up for the unknown long-term effects.

Název v anglickém jazyce

Osmium absorption after osmium tetroxide skin and eye exposure

Popis výsledku anglicky

Osmium tetroxide is a strong oxidizing agent used in electron microscopy. Eye exposure may cause severe burns, and after inhalation or ingestion damage to the respiratory or gastrointestinal tract occurs. Exposure to osmium and its compounds is extremely rare. We present a case of a 32-year-old female stained by 9 mL of 2% osmium tetroxide in acetone during an accident in the laboratory, with rare dermal and ocular findings. Due to lack of data in toxicological databases and the absence of antidote, the therapy was symptomatic. Osmium was detected in serum 19 hours later (0.22 mu g/L) and in urine during the 15-hour collection (three samples-7.05, 1.65 and 8.45 mu g/L). In blood serum on admission, after 1 and 2 days after exposure, the levels of iron (28.2, 39.8 and 50.5 mu mol/L; reference range 5.8-34.5 mu mol/L) and transferrin receptor/ferritine were elevated. To our knowledge, this is the first paper documenting a significant absorption from the skin and potentially from the eye conjunctiva, based on serum and urine analysis. The relationship between increased iron in blood and exposure has not been described yet, and the mechanism remains unknown. The patient is being followed up for the unknown long-term effects.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30304 - Public and environmental health

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Basic &amp; Clinical Pharmacology &amp; Toxicology

ISSN

1742-7835

e-ISSN

—

Svazek periodika

127

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

429-433

Kód UT WoS článku

000543394100001

EID výsledku v databázi Scopus

2-s2.0-85087165498