Validation Study of a German Cognitive Battery for Huntington's Disease: Relationship Between Cognitive Performance, Functional Decline, and Disease Burden

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10428770" target="_blank" >RIV/00216208:11110/21:10428770 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/21:10428770

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yDsY5OxCXA" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=yDsY5OxCXA</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/arclin/acaa038" target="_blank" >10.1093/arclin/acaa038</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Validation Study of a German Cognitive Battery for Huntington's Disease: Relationship Between Cognitive Performance, Functional Decline, and Disease Burden

Popis výsledku v původním jazyce

Objective: Cognitive decline is a key characteristic of Huntington&apos;s disease (HD). This study aimed to investigate the diagnostic accuracy of a cognitive battery with six tests used by most HD research centers to assess cognitive impairment in HD. Method: In total, 106 HD patients in different disease stages with more (HD-CD, N = 30) and less cognitive impairments (HD-NC, N = 70) and 100 healthy controls (NC) were matched by age, sex, and education and were examined using a standardized protocol including cognitive, motor, and functional assessments. Results: One-way between-groups analysis of variance showed that controls performed significantly better than HD patients and that HD-NC significantly outperformed HD-CD patients in all cognitive tests (NC &gt; HD-NC &gt; HD-CD), with all Games-Howell post-hoc tests p &lt; .001. Analyses using area under the receiver-operating characteristic curve (AUC) disclosed the diagnostic accuracy of all tests included in the battery to discriminate between NC and HD patients with AUC ranging from 0.809 to 0.862 (all p &lt; .001) and between HD-CD and HD-NC patients with AUC ranging from 0.833 to 0.899 (all p &lt; .001). In both analysis, Stroop Color Naming Test showed the highest discriminative potential. Additional analyses showed that cognitive deficits in all domains progressed with disease duration. Moreover, cognitive performance correlated with the severity of motor and functional impairment (all p &lt; .001) and with the Disease Burden Score regardless of disease duration and age. Conclusion: Our results indicate that the cognitive battery is a suitable tool for assessing cognitive impairment in HD.

Název v anglickém jazyce

Validation Study of a German Cognitive Battery for Huntington's Disease: Relationship Between Cognitive Performance, Functional Decline, and Disease Burden

Popis výsledku anglicky

Objective: Cognitive decline is a key characteristic of Huntington&apos;s disease (HD). This study aimed to investigate the diagnostic accuracy of a cognitive battery with six tests used by most HD research centers to assess cognitive impairment in HD. Method: In total, 106 HD patients in different disease stages with more (HD-CD, N = 30) and less cognitive impairments (HD-NC, N = 70) and 100 healthy controls (NC) were matched by age, sex, and education and were examined using a standardized protocol including cognitive, motor, and functional assessments. Results: One-way between-groups analysis of variance showed that controls performed significantly better than HD patients and that HD-NC significantly outperformed HD-CD patients in all cognitive tests (NC &gt; HD-NC &gt; HD-CD), with all Games-Howell post-hoc tests p &lt; .001. Analyses using area under the receiver-operating characteristic curve (AUC) disclosed the diagnostic accuracy of all tests included in the battery to discriminate between NC and HD patients with AUC ranging from 0.809 to 0.862 (all p &lt; .001) and between HD-CD and HD-NC patients with AUC ranging from 0.833 to 0.899 (all p &lt; .001). In both analysis, Stroop Color Naming Test showed the highest discriminative potential. Additional analyses showed that cognitive deficits in all domains progressed with disease duration. Moreover, cognitive performance correlated with the severity of motor and functional impairment (all p &lt; .001) and with the Disease Burden Score regardless of disease duration and age. Conclusion: Our results indicate that the cognitive battery is a suitable tool for assessing cognitive impairment in HD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Clinical Neuropsychology

ISSN

0887-6177

e-ISSN

—

Svazek periodika

36

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

74-86

Kód UT WoS článku

000649437300007

EID výsledku v databázi Scopus

2-s2.0-85100070017