Titanium and Other Metal Hypersensitivity Diagnosed by MELISA(R) Test: Follow-Up Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F21%3A10434987" target="_blank" >RIV/00216208:11110/21:10434987 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064165:_____/21:10434987

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=2YhKTfyOmb" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=2YhKTfyOmb</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2021/5512091" target="_blank" >10.1155/2021/5512091</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Titanium and Other Metal Hypersensitivity Diagnosed by MELISA(R) Test: Follow-Up Study

Popis výsledku v původním jazyce

This study is aimed at proving the clinical benefit of the MELISA(R) test in the minimization or complete elimination of health problems in patients with confirmed hypersensitivity to metals used for tissue replacements. A group of 305 patients aged 20-75 years with previously proven metal hypersensitivity (initial MELISA(R) test), mainly to titanium and then to another fifteen metals, was chosen from the database at the Institute of Dental Medicine. From these patients, a final group of 42 patients agreed to participate in the study, 35 of which were female and 7 were male. The patients completed a special questionnaire aimed at information regarding change of health status from their last visit and determining whether the results of the initial MELISA(R) test and recommendations based on it were beneficial for patients or not. They were clinically examined, and peripheral blood samples were taken to perform follow-up MELISA(R) tests. Questionnaire data was processed, and the follow-up MELISA(R) test results were compared with the results of the initial MELISA(R) tests. For statistical analysis, the Fisher&apos;s exact test and paired T-test were used. Thirty-two patients reported that they followed the recommendations based on the results of the initial MELISA(R) tests, and of these, 30 patients (94%) confirmed significant health improvement. Six patients did not follow the recommendation, and from these, only one patient reported an improvement in his health problems. By comparison of the initial and follow-up MELISA(R) test results, it can be stated that the hypersensitivity to the given metal decreased or disappeared after the therapeutic interventions performed based on the initial MELISA(R) test results. The evaluation of the data obtained from patients in this study confirmed a significant clinical benefit of MELISA(R) test.

Název v anglickém jazyce

Titanium and Other Metal Hypersensitivity Diagnosed by MELISA(R) Test: Follow-Up Study

Popis výsledku anglicky

This study is aimed at proving the clinical benefit of the MELISA(R) test in the minimization or complete elimination of health problems in patients with confirmed hypersensitivity to metals used for tissue replacements. A group of 305 patients aged 20-75 years with previously proven metal hypersensitivity (initial MELISA(R) test), mainly to titanium and then to another fifteen metals, was chosen from the database at the Institute of Dental Medicine. From these patients, a final group of 42 patients agreed to participate in the study, 35 of which were female and 7 were male. The patients completed a special questionnaire aimed at information regarding change of health status from their last visit and determining whether the results of the initial MELISA(R) test and recommendations based on it were beneficial for patients or not. They were clinically examined, and peripheral blood samples were taken to perform follow-up MELISA(R) tests. Questionnaire data was processed, and the follow-up MELISA(R) test results were compared with the results of the initial MELISA(R) tests. For statistical analysis, the Fisher&apos;s exact test and paired T-test were used. Thirty-two patients reported that they followed the recommendations based on the results of the initial MELISA(R) tests, and of these, 30 patients (94%) confirmed significant health improvement. Six patients did not follow the recommendation, and from these, only one patient reported an improvement in his health problems. By comparison of the initial and follow-up MELISA(R) test results, it can be stated that the hypersensitivity to the given metal decreased or disappeared after the therapeutic interventions performed based on the initial MELISA(R) test results. The evaluation of the data obtained from patients in this study confirmed a significant clinical benefit of MELISA(R) test.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30208 - Dentistry, oral surgery and medicine

Projekt

<a href="/cs/project/NV19-08-00070" target="_blank" >NV19-08-00070: Využití lymfocytů hypersenzitivních pacientů pro preklinické testování pokročilých materiálů na bázi titanu modifikovaných iontovým svazkem</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BioMed Research International

ISSN

2314-6133

e-ISSN

—

Svazek periodika

2021

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

5512091

Kód UT WoS článku

000750690300001

EID výsledku v databázi Scopus

2-s2.0-85108121416