Dopamine and Dopamine-Related Ligands Can Bind Not Only to Dopamine Receptors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F22%3A10445023" target="_blank" >RIV/00216208:11110/22:10445023 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=jH9.YQYMhZ" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=jH9.YQYMhZ</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/life12050606" target="_blank" >10.3390/life12050606</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dopamine and Dopamine-Related Ligands Can Bind Not Only to Dopamine Receptors

Popis výsledku v původním jazyce

The dopaminergic system is one of the most important neurotransmitter systems in the central nervous system (CNS). It acts mainly by activation of the D-1-like receptor family at the target cell. Additionally, fine-tuning of the signal is achieved via pre-synaptic modulation by the D-2-like receptor family. Some dopamine drugs (both agonists and antagonists) bind in addition to DRs also to alpha(2)-ARs and 5-HT receptors. Unfortunately, these compounds are often considered subtype(s) specific. Thus, it is important to consider the presence of these receptor subtypes in specific CNS areas as the function virtually elicited by one receptor type could be an effect of other-or the co-effect of multiple receptors. However, there are enough molecules with adequate specificity. In this review, we want to give an overview of the most common off-targets for established dopamine receptor ligands. To give an overall picture, we included a discussion on subtype selectivity. Molecules used as antipsychotic drugs are reviewed too. Therefore, we will summarize reported affinities and give an outline of molecules sufficiently specific for one or more subtypes (i.e., for subfamily), the presence of DR, alpha(2)-ARs, and 5-HT receptors in CNS areas, which could help avoid ambiguous results.

Název v anglickém jazyce

Dopamine and Dopamine-Related Ligands Can Bind Not Only to Dopamine Receptors

Popis výsledku anglicky

The dopaminergic system is one of the most important neurotransmitter systems in the central nervous system (CNS). It acts mainly by activation of the D-1-like receptor family at the target cell. Additionally, fine-tuning of the signal is achieved via pre-synaptic modulation by the D-2-like receptor family. Some dopamine drugs (both agonists and antagonists) bind in addition to DRs also to alpha(2)-ARs and 5-HT receptors. Unfortunately, these compounds are often considered subtype(s) specific. Thus, it is important to consider the presence of these receptor subtypes in specific CNS areas as the function virtually elicited by one receptor type could be an effect of other-or the co-effect of multiple receptors. However, there are enough molecules with adequate specificity. In this review, we want to give an overview of the most common off-targets for established dopamine receptor ligands. To give an overall picture, we included a discussion on subtype selectivity. Molecules used as antipsychotic drugs are reviewed too. Therefore, we will summarize reported affinities and give an outline of molecules sufficiently specific for one or more subtypes (i.e., for subfamily), the presence of DR, alpha(2)-ARs, and 5-HT receptors in CNS areas, which could help avoid ambiguous results.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Life [online]

ISSN

2075-1729

e-ISSN

2075-1729

Svazek periodika

12

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

19

Strana od-do

606

Kód UT WoS článku

000801740300001

EID výsledku v databázi Scopus

2-s2.0-85129269480