Injectable Hyaluronic Acid Hydrogel Containing Platelet Derivatives for Synovial Fluid Viscosupplementation and Growth Factors Delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F23%3A10459038" target="_blank" >RIV/00216208:11110/23:10459038 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=XUEQOOW6qu" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=XUEQOOW6qu</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mabi.202200516" target="_blank" >10.1002/mabi.202200516</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Injectable Hyaluronic Acid Hydrogel Containing Platelet Derivatives for Synovial Fluid Viscosupplementation and Growth Factors Delivery

Popis výsledku v původním jazyce

Osteoarthritisis a highly prevalent musculoskeletal disorder characterized by degradation ofcartilage and synovial fluid (SF). Platelet derivatives as platelet-rich plasma (PRP) and platelet lysatehave great potential in the treatment of osteoarthritis because they contain biologicallyactive substances including growth factors (GFs). Rapid release of GFs andtheir short biological half-life are factors that can limit the therapeuticimpact of PRP therapy. Here, the first work that describes hydrogels based onpolyaldehyde derivative of hyaluronic acid (HA-OX) as carriers of plateletderivatives for in situ applications is presented, which can be a possiblesolution to the problem. HA-OX hydrogels containing 50% (w/w) of PRP or platelet lysate can be injected using a syringe due to low viscosity(&lt;10 Pa s) and injection force (&lt;20 N), and reach elastic modulus upto 2000 Pa. Insulin-like GF-1 and Platelet-derived GF-AB release from HA-OX hydrogels (mesh size 297-406 nm) by Fickian and non-Fickian diffusion respectively. The released PRP GFs maintain their ability to induce cell proliferation (87%-92%). Based on the obtained results, the unique concept of a new material that canrestore viscoelastic properties of SF and at the same time gradually deliver GFs from platelet derivatives is designed.

Název v anglickém jazyce

Injectable Hyaluronic Acid Hydrogel Containing Platelet Derivatives for Synovial Fluid Viscosupplementation and Growth Factors Delivery

Popis výsledku anglicky

Osteoarthritisis a highly prevalent musculoskeletal disorder characterized by degradation ofcartilage and synovial fluid (SF). Platelet derivatives as platelet-rich plasma (PRP) and platelet lysatehave great potential in the treatment of osteoarthritis because they contain biologicallyactive substances including growth factors (GFs). Rapid release of GFs andtheir short biological half-life are factors that can limit the therapeuticimpact of PRP therapy. Here, the first work that describes hydrogels based onpolyaldehyde derivative of hyaluronic acid (HA-OX) as carriers of plateletderivatives for in situ applications is presented, which can be a possiblesolution to the problem. HA-OX hydrogels containing 50% (w/w) of PRP or platelet lysate can be injected using a syringe due to low viscosity(&lt;10 Pa s) and injection force (&lt;20 N), and reach elastic modulus upto 2000 Pa. Insulin-like GF-1 and Platelet-derived GF-AB release from HA-OX hydrogels (mesh size 297-406 nm) by Fickian and non-Fickian diffusion respectively. The released PRP GFs maintain their ability to induce cell proliferation (87%-92%). Based on the obtained results, the unique concept of a new material that canrestore viscoelastic properties of SF and at the same time gradually deliver GFs from platelet derivatives is designed.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30100 - Basic medicine

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Macromolecular Bioscience

ISSN

1616-5187

e-ISSN

1616-5195

Svazek periodika

23

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

14

Strana od-do

2200516

Kód UT WoS článku

000930163600001

EID výsledku v databázi Scopus

2-s2.0-85147939224