Prenatal morphine exposure differentially alters learning and memory in male and female rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F01%3A00003615" target="_blank" >RIV/00216208:11120/01:00003615 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/S0031-9384(01)00469-3" target="_blank" >http://dx.doi.org/10.1016/S0031-9384(01)00469-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/S0031-9384(01)00469-3" target="_blank" >10.1016/S0031-9384(01)00469-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prenatal morphine exposure differentially alters learning and memory in male and female rats

Popis výsledku v původním jazyce

The present study tested the hypothesis that exposure to morphine on prenatal days 11-18 impairs performance on tasks requiring learning and memory in adult male and female rats. In Experiment 1, a symmetrical maze was used to measure learning. In Experiment 2, an eight-arm radial maze was used to assess working spatial memory. The results of Experiment 1 demonstrated that prenatal morphine exposure reduces the time needed to complete the trials, but does not affect the accuracy of performance in male rats. In contrast, prenatal drug treatment had no effects on either the time or the accuracy of performance in female rats. In Experiment 2, both male and female morphine exposed rats needed more time to complete regular trials (no delay) than controls; however, morphine exposure in male rats did not affect performance on tasks requiring memory, measured with delay trials, but hindered it in ovariohysterectomized (OVX) female rats.

Název v anglickém jazyce

Prenatal morphine exposure differentially alters learning and memory in male and female rats

Popis výsledku anglicky

The present study tested the hypothesis that exposure to morphine on prenatal days 11-18 impairs performance on tasks requiring learning and memory in adult male and female rats. In Experiment 1, a symmetrical maze was used to measure learning. In Experiment 2, an eight-arm radial maze was used to assess working spatial memory. The results of Experiment 1 demonstrated that prenatal morphine exposure reduces the time needed to complete the trials, but does not affect the accuracy of performance in male rats. In contrast, prenatal drug treatment had no effects on either the time or the accuracy of performance in female rats. In Experiment 2, both male and female morphine exposed rats needed more time to complete regular trials (no delay) than controls; however, morphine exposure in male rats did not affect performance on tasks requiring memory, measured with delay trials, but hindered it in ovariohysterectomized (OVX) female rats.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/IZ3613" target="_blank" >IZ3613: Vliv chronické terapie antiepileptiky a časných postnatálních záchvatů na vývoj normálních mozkových funkcí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiology & Behavior

ISSN

0031-9384

e-ISSN

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Svazek periodika

73

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

93-103

Kód UT WoS článku

000169239400013

EID výsledku v databázi Scopus

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