Impact of methamphetamine administered prenatally and in adulthood on cognitive functions of male rats tested in Morris water maze

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F08%3A00000560" target="_blank" >RIV/00216208:11120/08:00000560 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Impact of methamphetamine administered prenatally and in adulthood on cognitive functions of male rats tested in Morris water maze

Popis výsledku v původním jazyce

Studies showed that stimulant drugs that affect the monoaminergic system alter both behavioral and cognitive processes. The aim of the present study was to investigate the impact of prenatal and acute methamphetamine (MA) exposure on cognitive functions of adult male rats tested in Morris water maze (MWM). We tested adult male rats prenatally exposed to MA (5 mg/kg), saline or no injection. Half of the animals were injected daily with MA (1 mg/kg) after finishing the testing. All injections were administered subcutaneously. Three types of tests were used: (1) "Place navigation test" (Learning), (2) "Probe test" (Probe) and (3) "Retention memory test" (Memory). Our results showed that prenatal MA exposure did not affect the test of learning and the Probe test. In the test of memory prenatally MA-exposed rats had lower latencies than animals prenatally exposed to saline. Further, acute MA administration increased the speed of swimming in all rats regardless of prenatal drug exposure and the type of test and, however, the increase in the speed was significantly greater in rats prenatally exposed to MA than in rats without any prenatal exposure. In addition, acute MA application significantly prolonged trajectories in the Place navigation test. The present study thus demonstrates that: (1) Prenatal MA exposure does not affect learning in the MWM. (2) Prenatal MA exposure increases the sensitivity to acute drug injection. (3) Acute MA application impairs learning in the MWM.

Název v anglickém jazyce

Impact of methamphetamine administered prenatally and in adulthood on cognitive functions of male rats tested in Morris water maze

Popis výsledku anglicky

Studies showed that stimulant drugs that affect the monoaminergic system alter both behavioral and cognitive processes. The aim of the present study was to investigate the impact of prenatal and acute methamphetamine (MA) exposure on cognitive functions of adult male rats tested in Morris water maze (MWM). We tested adult male rats prenatally exposed to MA (5 mg/kg), saline or no injection. Half of the animals were injected daily with MA (1 mg/kg) after finishing the testing. All injections were administered subcutaneously. Three types of tests were used: (1) "Place navigation test" (Learning), (2) "Probe test" (Probe) and (3) "Retention memory test" (Memory). Our results showed that prenatal MA exposure did not affect the test of learning and the Probe test. In the test of memory prenatally MA-exposed rats had lower latencies than animals prenatally exposed to saline. Further, acute MA administration increased the speed of swimming in all rats regardless of prenatal drug exposure and the type of test and, however, the increase in the speed was significantly greater in rats prenatally exposed to MA than in rats without any prenatal exposure. In addition, acute MA application significantly prolonged trajectories in the Place navigation test. The present study thus demonstrates that: (1) Prenatal MA exposure does not affect learning in the MWM. (2) Prenatal MA exposure increases the sensitivity to acute drug injection. (3) Acute MA application impairs learning in the MWM.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/GA305%2F06%2F0283" target="_blank" >GA305/06/0283: Senzitizace u dospělého laboratorního potkana vyvolaná prenatální expozicí metamfetaminu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Prague Medical Report

ISSN

1214-6994

e-ISSN

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Svazek periodika

109

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

62-70

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-59049101649