Gender differences in the effect of adult amphetamine on cognitive functions of rats prenatally exposed to methamphetamine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F14%3A43908432" target="_blank" >RIV/00216208:11120/14:43908432 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bbr.2014.04.040" target="_blank" >http://dx.doi.org/10.1016/j.bbr.2014.04.040</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbr.2014.04.040" target="_blank" >10.1016/j.bbr.2014.04.040</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gender differences in the effect of adult amphetamine on cognitive functions of rats prenatally exposed to methamphetamine

Popis výsledku v původním jazyce

Psychostimulants have been shown to affect brain regions involved in the process of learning and memory consolidation. It has been shown that females are more sensitive to the effects of drugs than males. The aim of our study was to investigate how prenatal methamphetamine (MA) exposure and application of amphetamine (AMP) in adulthood would affect spatial learning of adult female and male rats. Mothers of the tested offspring were exposed to injections of MA (5mg/kg) or saline (SA) throughout the entire gestation period. Cognitive functions of adult rats were evaluated in the Morris Water Maze (MWM) tests. Adult offspring were injected daily with AMP (5mg/kg) or SA through the period of MWM testing. Our data from the MWM tests demonstrates the following. Prenatal MA exposure did not change the learning ability of adult male and female rats. However, AMP administration to adult animals affected cognitive function in terms of exacerbation of spatial learning (increasing the latency to r

Název v anglickém jazyce

Gender differences in the effect of adult amphetamine on cognitive functions of rats prenatally exposed to methamphetamine

Popis výsledku anglicky

Psychostimulants have been shown to affect brain regions involved in the process of learning and memory consolidation. It has been shown that females are more sensitive to the effects of drugs than males. The aim of our study was to investigate how prenatal methamphetamine (MA) exposure and application of amphetamine (AMP) in adulthood would affect spatial learning of adult female and male rats. Mothers of the tested offspring were exposed to injections of MA (5mg/kg) or saline (SA) throughout the entire gestation period. Cognitive functions of adult rats were evaluated in the Morris Water Maze (MWM) tests. Adult offspring were injected daily with AMP (5mg/kg) or SA through the period of MWM testing. Our data from the MWM tests demonstrates the following. Prenatal MA exposure did not change the learning ability of adult male and female rats. However, AMP administration to adult animals affected cognitive function in terms of exacerbation of spatial learning (increasing the latency to r

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA305%2F09%2F0126" target="_blank" >GA305/09/0126: Vyvolává prenatální expozice metamfetaminu zkříženou citlivost k drogám u dospělých samců a samic laboratorního potkana?</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Behavioural Brain Research

ISSN

0166-4328

e-ISSN

—

Svazek periodika

270

Číslo periodika v rámci svazku

15 August

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

8-17

Kód UT WoS článku

000339694200002

EID výsledku v databázi Scopus

—