Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11120%2F02%3A00003123" target="_blank" >RIV/00216208:11120/02:00003123 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1038/sj/ijo/0801845" target="_blank" >http://dx.doi.org/10.1038/sj/ijo/0801845</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/sj/ijo/0801845" target="_blank" >10.1038/sj/ijo/0801845</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women

Popis výsledku v původním jazyce

We recently demonstrated that natriuretic peptides (NP) are involved in a pathway inducing lipolysis in human adipose tissue. Atrial NP (ANP) and brain NP (BNP) operate via a cGMP-dependent pathway which does not involve phosphodiesterase-3B inhibition or CAMP. The study was performed to evaluate the effect of ANP on lipid mobilization in obese women and secondly to examine the possible effect of a low-calorie diet (LCD) on the lipolytic response of subcutaneous abdominal fat cells to NP and on the lipid mobilization induced by ANP infusion (1 mug/m(2) min for 60 min). CONCLUSION: The present study shows that NP are powerful lipolytic agents in subcutaneous fat cells and that both isoproterenol- and NP-induced lipolysis increase during LCD, in obese women. These changes seem to be associated with an improvement of the lipolytic pathway at a post-receptor level. Moreover, Lv. administration of ANP induced a lipid mobilizing effect which was enhanced by a LCD in these objects.

Název v anglickém jazyce

Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women

Popis výsledku anglicky

We recently demonstrated that natriuretic peptides (NP) are involved in a pathway inducing lipolysis in human adipose tissue. Atrial NP (ANP) and brain NP (BNP) operate via a cGMP-dependent pathway which does not involve phosphodiesterase-3B inhibition or CAMP. The study was performed to evaluate the effect of ANP on lipid mobilization in obese women and secondly to examine the possible effect of a low-calorie diet (LCD) on the lipolytic response of subcutaneous abdominal fat cells to NP and on the lipid mobilization induced by ANP infusion (1 mug/m(2) min for 60 min). CONCLUSION: The present study shows that NP are powerful lipolytic agents in subcutaneous fat cells and that both isoproterenol- and NP-induced lipolysis increase during LCD, in obese women. These changes seem to be associated with an improvement of the lipolytic pathway at a post-receptor level. Moreover, Lv. administration of ANP induced a lipid mobilizing effect which was enhanced by a LCD in these objects.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

<a href="/cs/project/NB4674" target="_blank" >NB4674: Metabolismus tukové tkáně hodnocený metodami molekulární biologie u obesních z oblastí lišících se rizikem kardiovaskulárních chorob.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Obesity

ISSN

0307-0565

e-ISSN

—

Svazek periodika

26

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

24-32

Kód UT WoS článku

000173366200004

EID výsledku v databázi Scopus

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